Lee K-M, Lee M-C, Lee C-J, Chen Y-C, Hsu B-G
School of Medicine, Tzu Chi University, Hualien, Taiwan.
School of Medicine, Tzu Chi University, Hualien, Taiwan; Department of Surgery, Buddhist Tzu Chi General Hospital, Hualien, Taiwan.
Transplant Proc. 2018 Oct;50(8):2496-2501. doi: 10.1016/j.transproceed.2018.04.005. Epub 2018 Apr 11.
Low levels of natriuretic peptide may activate the renin-angiotensin-aldosterone system, which may contribute to the development of obesity. Therefore, in study we aim to evaluate the relationship between metabolic syndrome (MetS) and serum N-terminal pro‒B-type natriuretic peptide (NT-proBNP) concentration in kidney transplant recipients.
Fasting blood samples were obtained from 66 kidney transplant recipients. MetS and its components were defined using the diagnostic criteria of the International Diabetes Federation.
A total of 20 patients (30.3%) had MetS. Hypertension, prevalence of diabetes, use of statin or fibrate, body weight, body mass index, waist circumference, body fat mass, and levels of systolic blood pressure, total cholesterol, triglyceride, blood urea nitrogen, insulin, and HOMA-IR were higher, whereas the levels of high-density lipoprotein cholesterol and NT-proBNP were lower in patients with MetS. Logarithmically transformed creatinine and log-HOMA-IR were associated with NT-proBNP levels in a multivariable linear regression analysis. Multivariate logistic regression analysis revealed that NT-proBNP was an independent predictor of MetS in kidney transplant recipients.
Our study has revealed that fasting level of NT-proBNP was negatively associated with MetS and that serum creatinine and HOMA-IR were independent predictors of serum NT-proBNP level in kidney transplant recipients.
利钠肽水平较低可能会激活肾素-血管紧张素-醛固酮系统，这可能有助于肥胖的发展。因此，在本研究中，我们旨在评估肾移植受者中代谢综合征（MetS）与血清N末端B型利钠肽原（NT-proBNP）浓度之间的关系。
从66名肾移植受者中采集空腹血样。使用国际糖尿病联盟的诊断标准定义MetS及其组成成分。
共有20名患者（30.3%）患有MetS。患有MetS的患者高血压、糖尿病患病率、他汀类药物或贝特类药物的使用、体重、体重指数、腰围、体脂肪量以及收缩压、总胆固醇、甘油三酯、血尿素氮、胰岛素和HOMA-IR水平较高，而高密度脂蛋白胆固醇和NT-proBNP水平较低。在多变量线性回归分析中，对数转换后的肌酐和对数HOMA-IR与NT-proBNP水平相关。多变量逻辑回归分析显示，NT-proBNP是肾移植受者中MetS的独立预测因子。
我们的研究表明，NT-proBNP的空腹水平与MetS呈负相关，血清肌酐和HOMA-IR是肾移植受者血清NT-proBNP水平的独立预测因子。
