Departments of Internal Medicine (BCB) and Pulmonary, Critical Care, Allergy and Sleep Medicine (CS, CL), Medical University of South Carolina (MUSC), Charleston, South Carolina.
Am J Med Sci. 2014 Sep;348(3):215-8. doi: 10.1097/MAJ.0000000000000233.
Obstructive sleep apnea syndrome (OSAS) may be associated with cognitive impairment (CI). The goal of this study was to evaluate the impact of risk factors and continuous positive airway pressure (CPAP) on a screening tool for cognitive function.
The Mail-In Cognitive Function Screening Instrument (MCFSI) is a self-administered test designed to identify CI in the Alzheimer's Disease Cooperative Study. It was administered to 88 consecutive patients with OSAS attending the Medical University of South Carolina Sleep Clinic. An MCFSI score ≥5 was considered abnormal.
Data were analyzed on 61 patients after excluding missing and duplicate data. The MCFSI score was abnormal in 15 patients (25%). African Americans were more likely to be CPAP-noncompliant. Female gender and smoking were associated with abnormal MCFSI scores. CPAP-compliant patients were more likely to have normal MCFSI scores, although the difference was not statistically significant (P = 0.06).
CPAP-compliant patients showed a trend toward lower MCFSI scores. There may be gender and racial differences in CI related to OSAS, predisposing certain groups to worse morbidity. Appropriate treatment and compliance with CPAP could improve CI in OSAS. Larger studies with multivariate analyses are needed to identify relationships between individual OSAS and CI risk factors.
阻塞性睡眠呼吸暂停综合征（OSAS）可能与认知障碍（CI）有关。本研究的目的是评估危险因素和持续气道正压通气（CPAP）对认知功能筛查工具的影响。
邮寄认知功能筛查工具（MCFSI）是一种自我管理测试，旨在识别阿尔茨海默病合作研究中的 CI。它被递交给南卡罗来纳医科大学睡眠诊所的 88 名连续 OSAS 患者。MCFSI 得分≥5 被认为异常。
在排除缺失和重复数据后，对 61 名患者进行了数据分析。15 名患者（25%）的 MCFSI 评分异常。非裔美国人更有可能不遵守 CPAP 治疗。女性性别和吸烟与异常 MCFSI 评分相关。CPAP 依从性患者更有可能具有正常的 MCFSI 评分，尽管差异无统计学意义（P = 0.06）。
CPAP 依从性患者的 MCFSI 评分呈下降趋势。与 OSAS 相关的 CI 可能存在性别和种族差异，使某些群体更容易出现更严重的发病率。适当的治疗和 CPAP 依从性可以改善 OSAS 中的 CI。需要进行更大的多变量分析研究，以确定个别 OSAS 和 CI 危险因素之间的关系。
