2型糖尿病患者合并阻塞性睡眠呼吸暂停综合征时的认知功能障碍。
Cognitive dysfunction in type 2 diabetes patients accompanied with obstructive sleep apnea syndrome.
作者信息
Li Huanyin, Gong Qi, Shao Jinshan, Liu Xueyuan, Zhao Yanxin
机构信息
Huanyin Li, Department of Neurology, Tenth People's Hospital, Tongji University, 301# Middle Yanchang Road, Shanghai, 200072, China.
Qi Gong, Department of Neurology, Shanghai Minhang Central Hospital, 170# Xinsong Road, Shanghai201199, China.
出版信息
Pak J Med Sci. 2014 Nov-Dec;30(6):1388-92. doi: 10.12669/pjms.306.5861.
OBJECTIVE
To investigate cognitive dysfunction of type 2 diabetes patients accompanied with obstructive sleep apnea syndrome (OSAS), and to analyze its relevant characteristics.
METHODS
Total 115 type 2 diabetes patients were divided into OSAS group (O group, n=83) and non-OSAS group (N group, n=32); Physical examination patients (C1 group, n=64) and OSAS patients without diabetes (C2 group, n=47) served as the control group. Apnea-hypopnea index (AHI), nocturnal lowest saturation of pulse oxygen (LSPO2) and simple mental state examination scale (MMSE) were evaluated.
RESULTS
Among diabetes patients, patients with OSAS have lower glycated hemoglobin, platelet count, thrombocytocrit, MMSE score and lowest mean arterial oxygen than non-OSAS patients; cognitive dysfunction state and glycemic control of patients are related to their diabetic duration, and then along with increase of diabetic duration, glycemic control becomes poor, so that cognitive dysfunction becomes more and more obvious.
CONCLUSION
Along with increased diabetic duration in type 2 diabetes accompanied with OSAS, glycemic control becomes poor, so that cognitive dysfunction more easily occurs. Meanwhile, coagulation function of blood system in OSAS patients with diabetes is impacted to some extent.
目的
探讨2型糖尿病合并阻塞性睡眠呼吸暂停综合征（OSAS）患者的认知功能障碍，并分析其相关特征。
方法
将115例2型糖尿病患者分为OSAS组（O组，n = 83）和非OSAS组（N组，n = 32）；体检患者（C1组，n = 64）和无糖尿病的OSAS患者（C2组，n = 47）作为对照组。评估呼吸暂停低通气指数（AHI）、夜间脉搏氧最低饱和度（LSPO2）和简易精神状态检查表（MMSE）。
结果
在糖尿病患者中，OSAS患者的糖化血红蛋白、血小板计数、血小板压积、MMSE评分和最低平均动脉血氧均低于非OSAS患者；患者的认知功能障碍状态和血糖控制与其糖尿病病程有关，随着糖尿病病程的增加，血糖控制变差，认知功能障碍越来越明显。
结论
2型糖尿病合并OSAS患者随着糖尿病病程增加，血糖控制变差，更容易发生认知功能障碍。同时，糖尿病OSAS患者的血液系统凝血功能受到一定程度影响。
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