Mondal Rakesh, Sarkar Sumantra, Das Niloy Kumar, Chakravorti Swati, Hazra Avijit, Sabui Tapas, Nandi Madhumita, Ray Biman, Das Anjan, Ganguli Sushas
Division of Pediatric Rheumatology, Department of Pediatric Medicine, *Department of Pharmacology and #Department of Physiology, IPGMER Kolkata. Correspondence to: Dr Rakesh Mondal, Balarampur, Mahestala (PO), Kolkata 700 141, India.
Indian Pediatr. 2014 Mar;51(3):199-202. doi: 10.1007/s13312-014-0383-2.
To evaluate the growth pattern in children with juvenile idiopathic arthritis and its subtypes in comparison with age, sex and temporally matched controls.
Prospective study.
Pediatric rheumatology clinic of a tertiary care hospital in Eastern part of India.
Seventy-five children (2-12 years) diagnosed as juvenile idiopathic erthritis by International League of Associations for Rheumatology criteria and 75 age- and sex- matched controls.
Weight, height and body mass index were recorded at six monthly interval in both groups over a period of 3 years.
weight, height and body mass index.
Subtype distribution of juvenile idiopathic arthritis was: oligoarthritis (49%, n=37), rheumatoid factor negative polyarthritis (27%, n=20), rheumatoid factor positive polyarthritis (8%, n=6), systemic onset (15%, n=11) and enthesitis related arthritis (1.3%, n=1). Anthropometric parameters in children with juvenile idiopathic arthritis were not significant different from controls. Comparison between the subtypes showed significant differences in height (P=0.011), weight (P=0.005), and growth velocity (P=0.005), but not in body mass index. Systemic onset disease led to significant restriction in height (P=0.018; 95% CI 2.13-33.77) and weight (P=0.008; 95% CI 1.47-14.43) compared to controls. Growth velocity was significantly affected in rheumatoid factor positive polyarthritis (P=0.003; 95% CIO. 46-3.14).
Children with juvenile idiopathic arthritis do not have significantly lower values of anthropometric parameters compared to controls. Significant restriction in height and weight is seen in systemic onset disease, and growth velocity is significantly reduced in rheumatoid factor positive subjects.
评估幼年特发性关节炎患儿及其亚型的生长模式，并与年龄、性别相匹配的同期对照进行比较。
前瞻性研究。
印度东部一家三级护理医院的儿科风湿病诊所。
75名根据国际风湿病联盟标准诊断为幼年特发性关节炎的儿童（2至12岁）以及75名年龄和性别匹配的对照。
两组在3年期间每6个月记录一次体重、身高和体重指数。
体重、身高和体重指数。
幼年特发性关节炎的亚型分布为：少关节炎（49%，n = 37）、类风湿因子阴性多关节炎（27%，n = 20）、类风湿因子阳性多关节炎（8%，n = 6）、全身型（15%，n = 11）和附着点炎相关关节炎（1.3%，n = 1）。幼年特发性关节炎患儿的人体测量参数与对照组无显著差异。各亚型之间的比较显示，身高（P = 0.011）、体重（P = 0.005）和生长速度（P = 0.005）存在显著差异，但体重指数无差异。与对照组相比，全身型疾病导致身高（P = 0.018；95%可信区间2.13 - 33.77）和体重（P = 0.008；95%可信区间1.47 - 14.43）受到显著限制。类风湿因子阳性多关节炎患者的生长速度受到显著影响（P = 0.003；95%可信区间0.46 - 3.14）。
与对照组相比，幼年特发性关节炎患儿的人体测量参数值并无显著降低。全身型疾病患儿的身高和体重受到显著限制，类风湿因子阳性患儿的生长速度显著降低。
