Department of Pediatric Medicine, Child Growth & Anthropology Unit, Advanced Pediatrics Centre, Postgraduate Institute of Medical Education & Research (PGIMER), Chandigarh, India.
Department of Pediatric Medicine, Allergy & Immunology Unit, Advanced Pediatrics Centre, Postgraduate Institute of Medical Education & Research (PGIMER), Chandigarh, India.
Anthropol Anz. 2021 Nov 18;78(4):257-265. doi: 10.1127/anthranz/2021/1314.
To study growth pattern of weight and length/height in male and female children with Juvenile Idiopathic Arthritis (JIA). A total of 348 patients (boys: 182, girls: 166) aged 1 to 18 years, diagnosed as cases of JIA and categorized into oligoarthritis, polyarthritis and systemic arthritis were enrolled in this mixed-longitudinal study from Pediatric Rheumatology Clinic of Advanced Pediatrics Centre, PGIMER, Chandigarh, India. Weight and length/height measurements were recorded at approximately 6 monthly intervals in Growth Laboratory/Growth Clinic of the department over a period of 13 years. Mean (SD) for weight and length/height were computed. Unpaired Student's t-test was employed to ascertain gender differences. Analysis of variance and post-hoc Bonferroni tests were applied to evaluate inter-group differences. A regular increase in weight and length/height of all children representing three types of JIA was noticed throughout the study period. Maximum growth impairment was seen in patients with systemic JIA. Children with oligoarthritis were least affected. Boys with oligoarthritis, measured lighter and shorter than girls. Gender differences for children with polyarthritis demonstrated inconsistent trends. Boys with systemic JIA generally measured lighter than girls. Boys with systemic JIA measured taller than girls upto 4 years and thereafter they remained shorter till 14 years. As compared to normal children (2000 CDC), impaired weight and length/height growth attainments were recorded in oligoarthritis, polyarthritis and systemic JIA patients throughout the study span. However, the magnitude of this impairment appears to be related to the subtype of JIA.
研究男性和女性幼年特发性关节炎（JIA）患儿体重和身高/长度的生长模式。本混合纵向研究共纳入 348 名年龄在 1 至 18 岁的 JIA 患儿（男 182 例，女 166 例），这些患儿来自印度昌迪加尔 PGIMER 高级儿科中心儿科风湿病诊所，分为寡关节炎、多关节炎和全身型关节炎。在 13 年的时间里，在该部门的生长实验室/生长诊所，大约每 6 个月记录一次体重和身高/长度的测量值。计算体重和身高/长度的平均值（标准差）。采用未配对学生 t 检验确定性别差异。应用方差分析和事后 Bonferroni 检验评估组间差异。研究期间，所有三种类型 JIA 的患儿体重和身高/长度均呈规律增加。全身型 JIA 患儿的生长受损最严重。寡关节炎患儿受影响最小。寡关节炎男孩比女孩体重轻、身高矮。多关节炎患儿的性别差异表现出不一致的趋势。全身型 JIA 男孩的体重通常比女孩轻。全身型 JIA 男孩比女孩高，直到 4 岁，此后直到 14 岁他们一直比女孩矮。与正常儿童（2000CDC）相比，在整个研究期间，寡关节炎、多关节炎和全身型 JIA 患儿的体重和身高/长度生长均受损。然而，这种受损的程度似乎与 JIA 的亚型有关。
