椎间盘相关基因分析

Analysis of intervertebral disc-related genes.

作者信息

Wu D J, Chen K, Wei X Z, Ni H J, Yu S Z, Zhu X D, Li M

机构信息

Department of Orthopedic, Changhai Hospital of the Second Military Medical University, Shanghai, China.

Department of Orthopedic, Changhai Hospital of the Second Military Medical University, Shanghai, China

出版信息

Genet Mol Res. 2014 Mar 24;13(1):2032-8. doi: 10.4238/2014.March.24.7.

DOI:10.4238/2014.March.24.7

PMID:24737428

Abstract

Intervertebral disk disease is a common clinical disorder manifested by pain, ataxia, paresis, motor paralysis, and sensorimotor paralysis. The clinical features, diagnosis, and treatment of cervical and thoracolumbar disk disease have been unclear until now. In this study, some differentially expressed genes were identified, and a network was constructed based on these genes. Through the statistical analysis of nodes and the contrast of 2 more connectivity nodes, it was found that the nodes in the network are in an important position and play key roles. Several of these genes, including MAP2K6, MAP2K3, and MAPK14, belong to the MAP kinase family, and several genes, including RHOBTB2, RHOQ, and RHOH, belong to the RHO family. Therefore, we hypothesize that the development of intervertebral disk disease is related to MAP and RHO family proteins.

摘要

椎间盘疾病是一种常见的临床病症，表现为疼痛、共济失调、轻瘫、运动麻痹和感觉运动麻痹。迄今为止，颈椎和胸腰椎间盘疾病的临床特征、诊断和治疗尚不清楚。在本研究中，鉴定了一些差异表达基因，并基于这些基因构建了一个网络。通过对节点的统计分析以及与另外2个连接性更强的节点进行对比，发现网络中的节点处于重要位置并发挥关键作用。这些基因中的几个，包括MAP2K6、MAP2K3和MAPK14，属于丝裂原活化蛋白激酶（MAP）家族，还有几个基因，包括RHOBTB2、RHOQ和RHOH，属于RHO家族。因此，我们推测椎间盘疾病的发展与MAP和RHO家族蛋白有关。