Wang Jinhan, Lin Li, Wang Hua-Qing, Chen Naiyao
Tianjin Key Laboratory of Food Biotechnology, School of Biotechnology and Food Science, Tianjin University of Commerce, The East entrance to Jinba Road, Beichen, Tianjin, 300134, China.
Tumour Biol. 2014 Jul;35(7):6925-31. doi: 10.1007/s13277-014-1914-0. Epub 2014 Apr 17.
We sought to reassess the association of PLCE1 rs2274223 and susceptibility to esophageal cancer (EC) through a meta-analysis of published case-control studies. Using the PubMed and Embase, we identified nine articles including fourteen case-control studies (15,225 cases and 23,620 controls). ORs and 95 % confidence intervals (CIs) of GG vs. AA, GG + GA vs. AA, GG vs. GA + AA, G vs. A, and AG vs. AA genetic models were estimated for each study. All of the genetic models indicated a statistically significant positive association with EC risk. The association appeared most pronounced for carriers of GG genotype (GG vs. AA: OR, 1.35; 95 % CI, 1.17 to 1.57), and weakest for individuals carrying GA genotype (GA vs. AA: OR, 1.13; 95 % CI, 1.05 to 1.23). Stratification analyses showed similar results in the population of Asians and in esophageal squamous cell carcinoma (ESCC). This meta-analysis provides strong statistical evidence for an elevated risk of EC associated with PLCE1 rs2274223. The association remains significant in Asian population and ESCC. Further investigations are warranted to validate these findings.
我们试图通过对已发表的病例对照研究进行荟萃分析，重新评估PLCE1基因rs2274223与食管癌（EC）易感性之间的关联。利用PubMed和Embase数据库，我们检索到9篇文章，其中包括14项病例对照研究（15225例病例和23620例对照）。对每项研究估计了GG与AA、GG + GA与AA、GG与GA + AA、G与A以及AG与AA遗传模型的比值比（OR）和95%置信区间（CI）。所有遗传模型均显示与EC风险存在统计学显著的正相关。GG基因型携带者的关联最为明显（GG与AA：OR，1.35；95%CI，1.17至1.57），而携带GA基因型的个体关联最弱（GA与AA：OR，1.13；95%CI，1.05至1.23）。分层分析在亚洲人群和食管鳞状细胞癌（ESCC）中显示出相似的结果。这项荟萃分析为PLCE1基因rs2274223与EC风险升高之间的关联提供了强有力的统计学证据。这种关联在亚洲人群和ESCC中仍然显著。有必要进行进一步的研究来验证这些发现。
