睡眠剥夺对大鼠非快速眼动睡眠期脑电图慢波活动的影响。

Effect of sleep deprivation on EEG slow wave activity within non-REM sleep episodes in the rat.

作者信息

Trachsel L, Tobler I, Borbély A A

机构信息

Institute of Pharmacology, University of Zurich, Switzerland.

出版信息

Electroencephalogr Clin Neurophysiol. 1989 Aug;73(2):167-71. doi: 10.1016/0013-4694(89)90197-1.

DOI:10.1016/0013-4694(89)90197-1

PMID:2473885

Abstract

Recordings of 10 rats were obtained during the first 8 h of the light period under control conditions and after 24 h of sleep deprivation (SD). Non-rapid eye movement sleep (non-REMS) and EEG spectra in the range of 0.5-4.0 Hz were analyzed for 4 sec epochs. The time course of EEG slow wave activity within non-REMS episodes was closely approximated by a saturating exponential function. The time constant of approx. 50 sec varied little over consecutive 2 h periods and was not significantly changed by SD. The maximal level of EEG slow wave activity attained within non-REMS episodes (corresponding to the asymptote level of the fitted function) decreased over consecutive 2 h periods and was massively enhanced after SD. The study documents both the invariant and the homeostatically regulated aspect of the intraepisodic build-up of EEG slow wave activity.

摘要

在对照条件下以及睡眠剥夺（SD）24小时后，于光照期的前8小时内对10只大鼠进行记录。对非快速眼动睡眠（non - REMS）以及0.5 - 4.0赫兹范围内的脑电图频谱进行4秒时段的分析。非快速眼动睡眠阶段内脑电图慢波活动的时间进程通过饱和指数函数得到了紧密近似。约50秒的时间常数在连续的2小时时段内变化很小，并且未因睡眠剥夺而发生显著改变。非快速眼动睡眠阶段内达到的脑电图慢波活动的最大水平（对应于拟合函数的渐近线水平）在连续的2小时时段内下降，而在睡眠剥夺后大幅增强。该研究记录了脑电图慢波活动在发作期积累过程中不变的和受稳态调节的方面。