Vrána D, Gatěk J, Cwiertka K, Srámek V
Klin Onkol. 2014;27(2):143-5.
For a long period of time, axillary dissection represented a standard approach for axillary node management in the case of sentinel node biopsy positivity during early stage breast cancer treatment. In recent years, there has been a trend to highlight the morbidity of such an axillary procedure considering longterm survival of early stage breast cancer patients. Two big trials, AMAROS and Z0011, were initiated to answer the question whether axillary dissection should be performed in the case of positivity of axillary sentinel node considering the fact that more than 70% of these patients will have no metastasis found during the axillary dissection and such a procedure only increases the morbidity of the surgery. Considering the results of the above mentioned trials, axillary dissection may be avoided in the case of fulfilling of inclusion criteria of these trials without any impact on the patient survival. IBCSG 23- 01 study brought similar conclusion in the case of micrometastasis in axillary sentinel node.
在很长一段时间里，腋窝清扫术一直是早期乳腺癌治疗中前哨淋巴结活检呈阳性时腋窝淋巴结处理的标准方法。近年来，考虑到早期乳腺癌患者的长期生存情况，人们开始关注这种腋窝手术的发病率。为此开展了两项大型试验，即AMAROS试验和Z0011试验，以回答在腋窝前哨淋巴结阳性的情况下是否应进行腋窝清扫术这一问题，因为超过70%的此类患者在腋窝清扫术中未发现转移，而这样的手术只会增加手术的发病率。鉴于上述试验结果，在满足这些试验纳入标准的情况下，可以避免进行腋窝清扫术，且不会对患者生存产生任何影响。国际乳腺癌研究组（IBCSG）23-01研究在腋窝前哨淋巴结微转移的情况下也得出了类似结论。
