Grossman Chagai, Shemesh Joseph, Koren-Morag Nira, Bornstein Gil, Ben-Zvi Ilan, Grossman Ehud
Rheumatology unit, The Chaim Sheba Medical Center, Tel-Hashomer, Israel.
J Clin Hypertens (Greenwich). 2014 Jun;16(6):424-8. doi: 10.1111/jch.12313. Epub 2014 Apr 16.
Uric acid (UA) is associated with atherosclerosis, and coronary artery calcium (CAC) is a marker of atherosclerosis. The authors studied the association between UA and CAC. A total of 663 asymptomatic patients (564 men; mean age, 55±7 years) were evaluated for the presence of CAC. The study population was divided into three tertiles according to their UA levels, and the prevalence of CAC was compared between the tertiles. CAC was detected in 349 (53%) patients. Levels of UA were significantly higher in those with CAC than in those without CAC (5.6+1.2 vs 5.3+1.3; P=.003). The odds ratio for the presence of CAC in the highest vs lowest UA tertile was 1.72 (95% confidence interval, 1.17-2.51). The highest UA tertile remained associated with the presence of CAC after adjustment for known cardiovascular risk factors. The results show that high serum UA levels are associated with the presence of CAC.
尿酸（UA）与动脉粥样硬化相关，而冠状动脉钙化（CAC）是动脉粥样硬化的一个标志物。作者研究了UA与CAC之间的关联。总共663例无症状患者（564例男性；平均年龄55±7岁）接受了CAC检测。研究人群根据其UA水平分为三个三分位数组，并比较了三分位数组之间CAC的患病率。349例（53%）患者检测到CAC。有CAC的患者UA水平显著高于无CAC的患者（5.6+1.2 vs 5.3+1.3；P=0.003）。最高UA三分位数组与最低UA三分位数组相比，存在CAC的比值比为1.72（95%置信区间，1.17-2.51）。在对已知心血管危险因素进行校正后，最高UA三分位数组仍与CAC的存在相关。结果表明，高血清UA水平与CAC的存在相关。
