Kabza Michał, Ciomborowska Joanna, Makałowska Izabela
Labolatory of Bioinformatics, Faculty of Biology, Adam Mickiewicz University, Poznań, Poland.
Labolatory of Bioinformatics, Faculty of Biology, Adam Mickiewicz University, Poznań, Poland
Mol Biol Evol. 2014 Jul;31(7):1646-8. doi: 10.1093/molbev/msu139. Epub 2014 Apr 16.
Retrocopies of protein-coding genes, reverse transcribed and inserted into the genome copies of mature RNA, have commonly been categorized as pseudogenes with no biological importance. However, recent studies showed that they play important role in the genomes evolution and shaping interspecies differences. Here, we present RetrogeneDB, a database of retrocopies in 62 animal genomes. RetrogeneDB contains information about retrocopies, their genomic localization, parental genes, ORF conservation, and expression. To our best knowledge, this is the most complete retrocopies database providing information for dozens of species previously never analyzed in the context of protein-coding genes retroposition. The database is available at http://retrogenedb.amu.edu.pl.
蛋白质编码基因的反转录拷贝,即成熟RNA反转录并插入基因组中的拷贝,通常被归类为没有生物学重要性的假基因。然而,最近的研究表明,它们在基因组进化和塑造种间差异中发挥着重要作用。在此,我们展示了RetrogeneDB,一个包含62个动物基因组中反转录拷贝的数据库。RetrogeneDB包含有关反转录拷贝、其基因组定位、亲本基因、开放阅读框保守性和表达的信息。据我们所知,这是最完整的反转录拷贝数据库,为数十种以前从未在蛋白质编码基因反转录背景下分析过的物种提供信息。该数据库可在http://retrogenedb.amu.edu.pl获取。