Ueda G, Shimizu C, Shimizu H, Saito J, Tanaka Y, Inoue M, Tanizawa O
Department of Obstetrics and Gynecology, Osaka University Medical School, Japan.
Gynecol Oncol. 1989 Aug;34(2):164-9. doi: 10.1016/0090-8258(89)90134-0.
Small-cell and poorly differentiated carcinomas of the cervix were studied immunohistochemically for several neuroendocrine and epithelial markers. Neuroendocrine markers were frequently expressed in small-cell carcinomas with argyrophilia; of the seven such tumors, four were immunoreactive with anti-chromogranin, seven with antineuroendocrine, five with anti-Leu 7, and seven with anti-neuron-specific enolase. Only neuron-specific enolase, however, was expressed in two of the three small-cell carcinomas without argyrophilia. On the other hand, one of the epithelial markers, epithelial membrane antigen, was strongly positive in all three small-cell carcinomas without argyrophilia and all seven poorly differentiated carcinomas, while it was expressed only weakly and focally in all small-cell carcinomas with argyrophilia except in one case. In conclusion, it is suggested that the immunohistochemical demonstration of several neuroendocrine markers may be helpful in diagnosing neuroendocrine carcinoma of the cervix as a supplement to conventional light microscopy, silver staining, and electron microscopy.
对宫颈小细胞癌和低分化癌进行了几种神经内分泌和上皮标记物的免疫组织化学研究。神经内分泌标记物在嗜银性小细胞癌中经常表达；在7例此类肿瘤中，4例对抗嗜铬粒蛋白呈免疫反应，7例对抗神经内分泌呈免疫反应，5例对抗Leu 7呈免疫反应，7例对抗神经元特异性烯醇化酶呈免疫反应。然而，在3例无嗜银性的小细胞癌中，只有2例表达神经元特异性烯醇化酶。另一方面，上皮标记物之一的上皮膜抗原，在所有3例无嗜银性的小细胞癌和所有7例低分化癌中均呈强阳性，而在除1例外的所有嗜银性小细胞癌中仅呈弱表达且为局灶性表达。总之，提示几种神经内分泌标记物的免疫组织化学显示可能有助于诊断宫颈神经内分泌癌，作为对传统光学显微镜、银染色和电子显微镜检查的补充。
