Sugimori H, Iwasaka T, Fukuda K, Hayashi Y, Hachisuga T
Department of Obstetrics and Gynecology, Saga Medical School, Japan.
Gynecol Oncol. 1989 Aug;34(2):180-2. doi: 10.1016/0090-8258(89)90137-6.
Eighteen patients with advanced or recurrent carcinoma of the cervix were treated with a combination of peplomycin, vincristine, mitomycin-C, and cisplatin (POMP). Ten of the 16 evaluable patients (63%) responded, including 4 with a complete response. Median duration of the response was 7 months. Two of 6 with intrapelvic recurrent tumors responded to some extent following intraarterial infusion. The subcutaneous infusion of peplomycin was well accepted by the patients. Toxicity was tolerable. This regimen seemed to be one of the regimens which should be considered for the advanced or recurrent cervical cancer.
18例晚期或复发性宫颈癌患者接受了培普利霉素、长春新碱、丝裂霉素-C和顺铂联合治疗（POMP方案）。16例可评估患者中有10例（63%）有反应，其中4例完全缓解。反应的中位持续时间为7个月。6例盆腔内复发性肿瘤患者中有2例在动脉内灌注后有一定程度的反应。患者对培普利霉素皮下注射的接受度良好。毒性是可耐受的。该方案似乎是晚期或复发性宫颈癌应考虑的方案之一。
