Giannone L, Brenner D E, Jones H W, Greco F A, Burnett L S
Gynecol Oncol. 1987 Feb;26(2):178-82. doi: 10.1016/0090-8258(87)90271-x.
Sixteen patients with metastatic or recurrent carcinoma of the cervix were treated with combination chemotherapy consisting of mitomycin-C, vincristine, bleomycin, and cisplatin. Seven of 14 (50%) evaluable patients responded. In 2 patients all measurable disease resolved. Median duration of response was 4.5 months. Toxicity was severe and consisted of myelosuppression, pulmonary fibrosis, nausea, vomiting, stomatitis, asthenia, and fever. Two treatment-related deaths occurred. This combination chemotherapy regimen appears to have a response rate similar to other cisplatin containing regimens. Response durations were short and toxicity was severe.
16例转移性或复发性宫颈癌患者接受了由丝裂霉素C、长春新碱、博来霉素和顺铂组成的联合化疗。14例可评估患者中有7例（50%）有反应。2例患者所有可测量的病灶均消失。反应的中位持续时间为4.5个月。毒性严重，包括骨髓抑制、肺纤维化、恶心、呕吐、口腔炎、乏力和发热。发生了2例与治疗相关的死亡。这种联合化疗方案的反应率似乎与其他含顺铂的方案相似。反应持续时间短且毒性严重。
