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重振个性化医学：超越基因表达，尊重生物分子复杂性。

Revitalizing personalized medicine: respecting biomolecular complexities beyond gene expression.

机构信息

School of Chemical Engineering, Purdue University, West Lafayette, Indianapolis, USA.

2017 Stonebridge Way, Canton, Michigan, USA.

出版信息

CPT Pharmacometrics Syst Pharmacol. 2014 Apr 16;3(4):e110. doi: 10.1038/psp.2014.6.

DOI:10.1038/psp.2014.6
PMID:24739991
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4011166/
Abstract

Despite recent advancements in "omic" technologies, personalized medicine has not realized its fullest potential due to isolated and incomplete application of gene expression tools. In many instances, pharmacogenomics is being interchangeably used for personalized medicine, when actually it is one of the many facets of personalized medicine. Herein, we highlight key issues that are hampering the advancement of personalized medicine and highlight emerging predictive tools that can serve as a decision support mechanism for physicians to personalize treatments.

摘要

尽管近年来“组学”技术取得了进展，但由于基因表达工具的孤立和不完整应用，个性化医疗尚未发挥其最大潜力。在许多情况下，药物基因组学被用作个性化医疗的代名词，而实际上它只是个性化医疗的众多方面之一。在此，我们重点介绍了阻碍个性化医疗发展的关键问题，并强调了新兴的预测工具，这些工具可以作为医生个性化治疗的决策支持机制。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e032/4011166/0f85bfac51e5/psp20146f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e032/4011166/c39302983ea6/psp20146f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e032/4011166/fb7a31f9d043/psp20146f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e032/4011166/94b0d9637f18/psp20146f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e032/4011166/d6da65996db0/psp20146f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e032/4011166/0f85bfac51e5/psp20146f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e032/4011166/c39302983ea6/psp20146f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e032/4011166/fb7a31f9d043/psp20146f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e032/4011166/94b0d9637f18/psp20146f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e032/4011166/d6da65996db0/psp20146f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e032/4011166/0f85bfac51e5/psp20146f5.jpg

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