Miyagawa S, Okuchi T, Shiomi Y, Sakamoto K
Department of Dermatology, Nara Medical University, Japan.
J Am Acad Dermatol. 1989 Aug;21(2 Pt 2):343-6. doi: 10.1016/s0190-9622(89)80031-3.
Skin eruptions with features of subacute cutaneous lupus erythematosus occurred in a patient with dermatomyositis who was taking griseofulvin. The patient had antibodies against SSA/Ro and SSB/La antigens. Skin rashes disappeared after discontinuation of griseofulvin and recurred on challenge with the drug. These findings support previous studies that the photoactive drug may be synergistic with anti-SSA/Ro antibody to produce lesions of subacute cutaneous lupus erythematosus.
一名正在服用灰黄霉素的皮肌炎患者出现了具有亚急性皮肤型红斑狼疮特征的皮肤疹。该患者具有抗SSA/Ro和SSB/La抗原的抗体。停用灰黄霉素后皮疹消失，再次使用该药物时皮疹复发。这些发现支持了先前的研究，即这种光活性药物可能与抗SSA/Ro抗体协同作用，产生亚急性皮肤型红斑狼疮的病变。
