Vlasses P H, Rotmensch H H, Swanson B N, Clementi R A, Ferguson R K
Department of Medicine, Jefferson Medical College of Thomas Jefferson University, Philadelphia, PA 19107.
J Endocrinol Invest. 1989 Feb;12(2):87-91. doi: 10.1007/BF03349926.
To evaluate changes in serum prolactin and plasma and urine aldosterone after a serotonergic challenge, 8 healthy men (19 to 42 yr), taking dexamethasone (0.75 mg qid), received the serotonin precursor L-5-hydroxytryptophan (L5HTP; 100 mg qid) with the peripheral decarboxylase inhibitor carbidopa (C; 50 mq qid) or matching placebos in a randomized, crossover manner. Serum prolactin concentration increased in all subjects after L5HTP/C in comparison to placebo, mean (SD) prolactin (ng/ml) at 8 h after dosing was 19.8 +/- 6.3 after L5HTP/C and 12.0 +/- 3.1 after placebo (p less than 0.05). In contrast, in comparison to values on placebo, L5HTP/C had no apparent effect on mean plasma concentration at all observation times; mean (SD) aldosterone (ng/dl) at 8 h after dosing was 12.0 +/- 5.1 and 12.0 +/- 3.8 after placebo (NS). Mean (SD) urinary aldosterone (micrograms/24 h), Na+(mEq/24 h) and K+(mEq/24 h) excretion were 7.0 +/- 4.4, 49.3 +/- 30.6, 30.1 +/- 11.2, after L5HTP/C and 7.4 +/- 5.8, 59.7 +/- 23.9, 33.3 +/- 7.4 after placebo (NS). Under these study conditions, subacute serotonergic stimulation with oral L5HTP/C resulted in prolactin but not aldosterone release.
为评估血清素激发后血清催乳素、血浆和尿醛固酮的变化，8名健康男性（19至42岁），正在服用地塞米松（每日4次，每次0.75毫克），以随机、交叉方式接受血清素前体L - 5 - 羟色氨酸（L5HTP；每日4次，每次100毫克）与外周脱羧酶抑制剂卡比多巴（C；每日4次，每次50毫克）或匹配的安慰剂。与安慰剂相比，所有受试者在服用L5HTP/C后血清催乳素浓度均升高，给药后8小时催乳素的平均（标准差）浓度（纳克/毫升）在服用L5HTP/C后为19.8±6.3，服用安慰剂后为12.0±3.1（p＜0.05）。相比之下，与安慰剂的值相比，L5HTP/C在所有观察时间对平均血浆浓度均无明显影响；给药后8小时醛固酮的平均（标准差）浓度（纳克/分升）在服用安慰剂后为12.0±5.1和12.0±3.8（无显著性差异）。服用L5HTP/C后尿醛固酮的平均（标准差）排泄量（微克/24小时）、钠（毫当量/24小时）和钾（毫当量/24小时）分别为7.0±4.4、49.3±30.6、30.1±11.2，服用安慰剂后分别为7.4±5.8、59.7±23.9、33.3±7.4（无显著性差异）。在这些研究条件下，口服L5HTP/C进行亚急性血清素刺激可导致催乳素释放，但不会导致醛固酮释放。
