Shenker Y, Gross M D, Grekin R J
J Clin Endocrinol Metab. 1985 Dec;61(6):1201-4. doi: 10.1210/jcem-61-6-1201.
To assess the effects of serotonin receptor blockade on 5-hydroxytryptophan (5HTP)-induced aldosterone secretion, we studied six normal men using the serotonin antagonists ketanserin and methysergide. The subjects were studied on three separate occasions, and pretreatment with dexamethasone was given before each study. On two occasions, the pretreatment period also included administration of a serotonin antagonist, either ketanserin (120 mg/day) or methysergide (6 mg/day). On the day of study, the subjects were given a single oral 200-mg dose of 5HTP. Plasma levels of aldosterone increased significantly after 5HTP treatment compared to basal levels during each stage of the study. No significant difference in response in the three studies was found. We conclude that peripheral blockade of serotonin2 receptors does not abolish 5HTP-induced aldosterone stimulation, and that this stimulation is most likely mediated by central pathways.
为评估血清素受体阻断对5-羟色氨酸（5HTP）诱导的醛固酮分泌的影响，我们使用血清素拮抗剂酮色林和麦角酰二乙胺对6名正常男性进行了研究。受试者在三个不同时段接受研究，每次研究前均给予地塞米松预处理。有两次，预处理期还包括给予一种血清素拮抗剂，要么是酮色林（120毫克/天），要么是麦角酰二乙胺（6毫克/天）。在研究当天，给受试者单次口服200毫克剂量的5HTP。与研究各阶段的基础水平相比，5HTP治疗后醛固酮的血浆水平显著升高。三项研究中的反应未发现显著差异。我们得出结论，血清素2受体的外周阻断并不能消除5HTP诱导的醛固酮刺激，并且这种刺激很可能是由中枢途径介导的。
