Brakoulias Vlasios, Starcevic Vladan, Berle David, Milicevic Denise, Hannan Anthony, Viswasam Kirupamani, Mann Kristy
Nepean Hospital, Sydney, Australia
Department of Psychiatry, Nepean Hospital, Penrith, Australia.
Aust N Z J Psychiatry. 2014 Sep;48(9):852-60. doi: 10.1177/0004867414531831. Epub 2014 Apr 16.
This study aims to examine the characteristics of obsessive compulsive disorder (OCD) associated with high levels of schizotypy.
Using the Schizotypal Personality Questionnaire (SPQ) with 177 individuals with OCD, patients with OCD and high levels of schizotypy (OCD-HS) were compared to patients with OCD and low levels of schizotypy (OCD-LS) on a range of clinical characteristics. Self-report and clinician-administered instruments were used. Results were adjusted for the severity of OCD symptoms, age, marital status and comorbidity using logistic regression.
Patients with OCD-HS were younger and less likely to have been married. OCD-HS was associated with higher rates of symmetry/order obsessions, ordering/arranging compulsions, checking compulsions, co-occurring major depression, post-traumatic stress disorder, substance use disorders and greater general psychopathology. Previously reported associations, such as higher total scores on the Yale-Brown Obsessive Compulsive Scale (Y-BOCS) were not significant when adjusted for differences in demographic variables and comorbidity.
Patients with OCD-HS were associated with specific OCD symptoms and comorbid conditions and may warrant a specific treatment approach.
本研究旨在探讨与高度精神分裂症型人格特质相关的强迫症(OCD)的特征。
对177名强迫症患者使用精神分裂症型人格问卷(SPQ),将强迫症且精神分裂症型人格特质水平高(OCD-HS)的患者与强迫症且精神分裂症型人格特质水平低(OCD-LS)的患者在一系列临床特征上进行比较。使用了自我报告和临床医生管理的工具。结果通过逻辑回归对强迫症症状的严重程度、年龄、婚姻状况和共病情况进行了调整。
OCD-HS患者更年轻且结婚的可能性更小。OCD-HS与对称/秩序强迫观念、整理/排列强迫行为、检查强迫行为、同时出现的重度抑郁症、创伤后应激障碍、物质使用障碍以及更严重的一般精神病理学的发生率更高有关。在对人口统计学变量和共病差异进行调整后,先前报道的关联,如耶鲁-布朗强迫症量表(Y-BOCS)上更高的总分并不显著。
OCD-HS患者与特定的强迫症症状和共病情况相关,可能需要特定的治疗方法。