一种合成N-磺酰基β(2,3)-氨基酯的多组分方法。
A multicomponent approach to the synthesis of N-sulfonyl β(2,3)-amino esters.
作者信息
Le Gall Erwan, Sengmany Stéphane, Samb Issa, Benakrour Sabrina, Colin Christopher, Pignon Antoine, Léonel Eric
机构信息
Électrochimie et Synthèse Organique, Institut de Chimie et des Matériaux Paris-Est, UMR 7182 CNRS - Université Paris-Est, 2-8 rue Henri Dunant, 94320 Thiais, France.
出版信息
Org Biomol Chem. 2014 Jun 7;12(21):3423-6. doi: 10.1039/c3ob42353k. Epub 2014 Apr 17.
The multicomponent synthesis of α,β-disubstituted N-sulfonyl β-amino esters is described. It involves a zinc-mediated, cobalt-catalyzed three-component reaction between sulfonylimines, acrylates and organic bromides. A possible mechanism is proposed, emphasizing the intermediate formation of an organocobalt as the initiator of a Mannich-like process.
描述了α,β-二取代N-磺酰基β-氨基酯的多组分合成。它涉及磺酰亚胺、丙烯酸酯和有机溴化物之间的锌介导、钴催化的三组分反应。提出了一种可能的机理，强调了有机钴中间体的形成是类曼尼希反应过程的引发剂。
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