Gui Qingwen, Dai Fenglin, Liu Jidan, Chen Peixing, Yang Zhiyong, Chen Xiang, Tan Ze
State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, P. R. China.
Org Biomol Chem. 2014 Jun 7;12(21):3349-53. doi: 10.1039/c4ob00118d. Epub 2014 Apr 17.
A highly efficient method for the synthesis of N-alkyl isatins starting from N-alkyl 2-bromo or 2-chloro acetanilides is described. The starting materials are easy to prepare and the yields of isatins are generally high. Operationally the reaction is very simple to run. Even though best results were obtained with a catalytic amount of CuI, the reactions of N-alkyl 2-bromo acetanilides actually performed well even in the absence of any metal catalyst.
描述了一种从N-烷基2-溴或2-氯乙酰苯胺开始合成N-烷基异吲哚酮的高效方法。起始原料易于制备，异吲哚酮的产率通常很高。在操作上，该反应运行非常简单。尽管使用催化量的碘化亚铜可获得最佳结果，但即使在没有任何金属催化剂的情况下，N-烷基2-溴乙酰苯胺的反应实际上也能顺利进行。
