Satish Gandhesiri, Polu Ashok, Ramar Thangeswaran, Ilangovan Andivelu
†School of Chemistry, Bharathidasan University, Tiruchirappalli 620024, India.
‡Syngene International Limited, Bangalore 560 099, India.
J Org Chem. 2015 May 15;80(10):5167-75. doi: 10.1021/acs.joc.5b00581. Epub 2015 May 4.
Molecular iodine-promoted efficient construction of isatins from 2'-aminophenylacetylenes, 2'-aminostyrenes, and 2'-amino-β-ketoesters is developed via oxidative amidation of sp, sp(2), and sp(3) C-H bonds. The reaction involves consecutive iodination, Kornblum oxidation, and intramolecular amidation in a single reactor. The present method meets all of the atom and redox economy principles.
通过sp、sp(2)和sp(3)碳氢键的氧化酰胺化反应，开发了分子碘促进的由2'-氨基苯乙炔、2'-氨基苯乙烯和2'-氨基-β-酮酯高效构建异吲哚酮的方法。该反应在单一反应器中涉及连续的碘化、科恩布卢姆氧化和分子内酰胺化。本方法符合所有原子和氧化还原经济原则。
