Nishida T, Nagasue N, Arimatsu T, Nagano H, Izumi S, Okura N, Matsumura T, Yakushiji M
Department of Obstetrics and Gynecology, National Kokura Hospital, Fukuoka.
Nihon Sanka Fujinka Gakkai Zasshi. 1989 May;41(5):590-4.
A combination chemotherapy of ifosfamide, adriamycin and cisplatin (IAP) plus bleomycin (IAP plus B) was used to treat nine patients with recurrent cervical cancer of the uterus. All patients had received conventional radiation therapy with or without hydroxyurea as a potential radiation sensitizer, and seven of them had measurable disease in a previous irradiated field (4 cases) or distant area (3 cases). The tumors included 5 squamous cell carcinomas (non keratinizing: 2, keratinizing: 3), two adenosquamous (including one glassy cell carcinoma), one adenocarcinoma (endometrioid type) and one argyrophil cell carcinoma. All histologic type cancers except argyrophil cell carcinoma responded to IAP plus B treatment. In seven evaluable cases, three complete responses (CR) and 3 partial responses (PR) were recorded (response rate was 85.7%), including 3 responded tumors within previously irradiated pelvic tissue. The median duration of CR was over 7 months and that of PR was 3.5 months. Side effects of IAP plus B were severe in hematologic toxicity (100% of grade 4 leucopenia) but acceptable, permitting five courses of treatments at four week intervals. The results obtained were encouraging, although therapeutic benefits of IAP plus B were not evident in a patient with argyrophil cell carcinoma and the intractable nature of this histologic type cancer in the uterine cervix was again emphasized.
采用异环磷酰胺、阿霉素和顺铂（IAP）联合博来霉素（IAP加B）的联合化疗方案治疗9例复发性子宫颈癌患者。所有患者均接受了常规放疗，部分患者加用羟基脲作为潜在的放疗增敏剂，其中7例患者在先前照射野（4例）或远处区域（3例）有可测量的病灶。肿瘤包括5例鳞状细胞癌（非角化型：2例，角化型：3例）、2例腺鳞癌（包括1例玻璃样细胞癌）、1例腺癌（子宫内膜样型）和1例嗜银细胞癌。除嗜银细胞癌外，所有组织学类型的癌症对IAP加B治疗均有反应。在7例可评估的病例中，记录到3例完全缓解（CR）和3例部分缓解（PR）（缓解率为85.7%），其中3例反应性肿瘤位于先前照射的盆腔组织内。CR的中位持续时间超过7个月，PR的中位持续时间为3.5个月。IAP加B的副作用主要是严重的血液学毒性（4级白细胞减少发生率为100%），但尚可接受，允许每4周进行5个疗程的治疗。尽管IAP加B对1例嗜银细胞癌患者的治疗效果不明显，再次强调了这种组织学类型的子宫颈癌的难治性，但所获得的结果令人鼓舞。
