Hardarson T, Kristinsson A, Skúladóttir G, Asvaldsdóttir H, Snorrason S P
Department of Medicine, National University Hospital, Landspitalinn, Iceland.
J Intern Med. 1989 Jul;226(1):33-7. doi: 10.1111/j.1365-2796.1989.tb01350.x.
Previous work has shown that in experimental animal models a lower incidence of arrhythmias and sudden death was observed if the animals were fed cod liver oil or fish oil. After a 48-h control period starting, on average, 8 days after the onset of symptoms, 18 men who were recovering from acute myocardial infarction were given 20 ml d-1 cod liver oil for 6 weeks, either immediately after the control period, weeks 0-6 (n = 10), or during weeks 6-12 (n = 8). Forty-eight-hour Holter monitoring was carried out before cod liver oil administration and at the end of weeks 6 and 12. The eicosapentaenoic acid content of plasma phospholipids was increased by 230% during cod liver oil administration. However, no significant change was observed in the 24-h prevalence of ventricular extrasystoles or other arrhythmias during the study period. The mean ln number of ventricular extrasystoles was 2.95 +/- 0.51 (+/- SEM) during cod liver oil ingestion and 2.63 +/- 0.30 when not taking cod liver oil.
先前的研究表明，在实验动物模型中，如果给动物喂食鱼肝油或鱼油，心律失常和猝死的发生率会降低。在平均于症状出现后8天开始的48小时对照期后，18名急性心肌梗死恢复期的男性，在对照期结束后立即（0 - 6周，n = 10）或在6 - 12周期间（n = 8），连续6周每天服用20毫升鱼肝油。在服用鱼肝油前以及第6周和第12周结束时进行了48小时动态心电图监测。在服用鱼肝油期间，血浆磷脂中的二十碳五烯酸含量增加了230%。然而，在研究期间，室性早搏或其他心律失常的24小时发生率没有显著变化。服用鱼肝油期间室性早搏的平均自然对数为2.95±0.51（±标准误），未服用鱼肝油时为2.63±0.30。
