Weiner B H, Ockene I S, Levine P H, Cuénoud H F, Fisher M, Johnson B F, Daoud A S, Jarmolych J, Hosmer D, Johnson M H
N Engl J Med. 1986 Oct 2;315(14):841-6. doi: 10.1056/NEJM198610023151401.
We studied the effect of cod-liver oil on the development and progression of coronary artery disease in swine subjected to coronary balloon abrasion and fed an atherogenic diet for eight months. Sections from serial 3-mm segments of the coronary arteries were analyzed morphometrically in 7 pigs given a cod-liver-oil supplement and 11 control animals not given the supplement. Significantly less disease was seen in the sections from the animals fed cod-liver oil. The mean lesion area per vessel, mean luminal encroachment per vessel, and mean maximal luminal encroachment per vessel were reduced in animals fed cod-liver oil, as compared with controls, (P = 0.05, P = 0.016, and P = 0.011, respectively). Both groups of animals had severe hyperlipidemia throughout the study. Differences in the extent of coronary atherosclerosis were not related to differences in plasma lipid levels. Platelet arachidonate was markedly reduced, platelet eicosapentaenoic acid was increased, and serum thromboxane was decreased in the oil-fed group as compared with the control group. We conclude that in our animal mode, dietary cod-liver oil retarded the development of coronary artery disease, possibly through changes in prostaglandin metabolism.
我们研究了鱼肝油对接受冠状动脉球囊磨损并喂食致动脉粥样化饮食八个月的猪的冠状动脉疾病发展和进程的影响。对7只补充鱼肝油的猪和11只未补充鱼肝油的对照动物的冠状动脉连续3毫米节段切片进行形态计量分析。在喂食鱼肝油的动物的切片中观察到的疾病明显较少。与对照组相比，喂食鱼肝油的动物每只血管的平均病变面积、每只血管的平均管腔狭窄程度和每只血管的平均最大管腔狭窄程度均降低（分别为P = 0.05、P = 0.016和P = 0.011）。在整个研究过程中，两组动物均患有严重的高脂血症。冠状动脉粥样硬化程度的差异与血浆脂质水平的差异无关。与对照组相比，喂食鱼肝油组的血小板花生四烯酸明显减少，血小板二十碳五烯酸增加，血清血栓素减少。我们得出结论，在我们的动物模型中，膳食鱼肝油可能通过前列腺素代谢的变化延缓了冠状动脉疾病的发展。
