Stoter G, Koopman A, Vendrik C P, Struyvenberg A, Sleyfer D T, Willemse P H, Schraffordt Koops H, van Oosterom A T, ten Bokkel Huinink W W, Pinedo H M
Free University Hospital, Amsterdam, The Netherlands.
J Clin Oncol. 1989 Aug;7(8):1099-104. doi: 10.1200/JCO.1989.7.8.1099.
This 10-year follow-up study of 91 patients with disseminated testicular nonseminomatous cancer, treated with cisplatin, vinblastine, and bleomycin (PVB) induction chemotherapy and vinblastine plus bleomycin maintenance chemotherapy for a planned period of 2 years, shows a 63% cure rate. The predominant long-term sequelae are neurological and sexual dysfunction in 68% and 40% of patients, respectively. Two patients died of myocardial infarction. Sixteen percent of patients developed hypertension, 23% Raynaud's phenomenon, and 25% ototoxicity. Despite the long-term side effects, 90% of the patients who responded to a questionnaire are fully employed. This study shows that the maintenance chemotherapy has contributed to the incidence and/or degree of neurotoxicity, hypertension, and renal function disturbance.
这项对91例播散性睾丸非精原细胞瘤患者进行的10年随访研究显示，治愈率为63%。这些患者接受了顺铂、长春碱和博来霉素（PVB）诱导化疗，并计划接受为期2年的长春碱加博来霉素维持化疗。主要的长期后遗症分别是68%的患者出现神经功能障碍，40%的患者出现性功能障碍。两名患者死于心肌梗死。16%的患者出现高血压，23%的患者出现雷诺现象，25%的患者出现耳毒性。尽管有长期副作用，但回复问卷的患者中有90%仍在全职工作。这项研究表明，维持化疗增加了神经毒性、高血压和肾功能障碍的发生率和/或严重程度。
