Gugic Jasenka, Zaletel Lorna Zadravec, Oblak Irena
Department of Radiotherapy, Institute of Oncology Ljubljana, Ljubljana, Slovenia.
Radiol Oncol. 2016 Apr 19;51(2):221-227. doi: 10.1515/raon-2016-0021. eCollection 2017 Jun.
Testicular cancer is the most common malignancy in young men. Considering increasing incidence, exceptionally high cure rate, as well as long life expectancy, assessment of long term toxicity in testicular cancer survivors is of great importance. In the last decades a major effort has been made in order to reduce toxicity of treatment, while maintaining its high effectiveness.
Actual knowledge on treatment toxicity is based on outdated treatment modalities. Hopefully, modern treatment modalities could reduce toxicity, but, there is no firm confirmation for that at the moment, as data dealing with late sequelae of modern treatment of testicular cancer are not available yet due to the short period of observation. The life-threatening cardiovascular toxicity in testicular cancer survivors is major complication of platinum-based chemotherapy, mediastinal radiotherapy and even subdiaphragmatic radiotherapy.
睾丸癌是年轻男性中最常见的恶性肿瘤。鉴于其发病率不断上升、治愈率极高以及预期寿命较长，评估睾丸癌幸存者的长期毒性至关重要。在过去几十年里，人们做出了重大努力以降低治疗毒性，同时保持其高效性。
目前关于治疗毒性的实际认知基于过时的治疗方式。有望现代治疗方式能降低毒性，但目前尚无确凿证据支持这一点，因为由于观察期较短，尚无关于睾丸癌现代治疗晚期后遗症的数据。睾丸癌幸存者中危及生命的心血管毒性是铂类化疗、纵隔放疗甚至膈下放疗的主要并发症。
