[智利一组感染艾滋病毒男性样本中维生素D缺乏症的高发生率及低骨矿物质密度]

[High frequency of hypovitaminosis D and low bone mineral density in a sample of HIV-infected men in Chile].

作者信息

Pérez Carlos, Ceballos María Elena

出版信息

Rev Chilena Infectol. 2014 Feb;31(1):44-6. doi: 10.4067/S0716-10182014000100006.

DOI:10.4067/S0716-10182014000100006

PMID:24740773

Abstract

OBJECTIVES

The aim of this study was to determine the frequency of hypovitaminosis D and low bone mineral density in a sample of patients within our HIV cohort.

METHODS

A random sample of 16 HIV-infected patients was selected for evaluation of levels of Vitamin D and bone mineral density with dual X ray absorptiometry.

RESULTS

Within this sample of patients, 94% had low levels of vitamin D. Among them, eight had insufficient levels (10-30 ng/mL) and seven had deficient levels (less than 10 ng/mL) of this vitamin. Ten out of sixteen (63%) had an abnormal dual X ray absorptiometry (osteopenia or osteoporosis). All patients with osteopenia or osteoporosis had low levels of vitamin D, were on CDC stage A, had a CD4+ count greater than 350 cells/mm³ and HIV viral load less than 50 copies/mL.

CONCLUSIONS

Low bone mineral density and hypovitaminosis D is highly frequent in this sample of HIV-infected patients in Chile.

摘要

目的

本研究的目的是确定我们艾滋病毒队列中患者样本中维生素D缺乏症和低骨矿物质密度的发生率。

方法

随机抽取16例感染艾滋病毒的患者，用双能X线吸收法评估维生素D水平和骨矿物质密度。

结果

在该患者样本中，94%的患者维生素D水平较低。其中，8例维生素水平不足（10 - 30 ng/mL），7例维生素水平缺乏（低于10 ng/mL）。16例中有10例（63%）双能X线吸收法结果异常（骨质减少或骨质疏松）。所有骨质减少或骨质疏松的患者维生素D水平均较低，处于疾病控制中心A期，CD4 + 细胞计数大于350个细胞/mm³，艾滋病毒载量低于50拷贝/mL。