Sutcliffe N P, Cashman S J, Savage C O, Fox J G, Boulton-Jones J M
Renal Unit, Glasgow Royal Infirmary, Scotland, UK.
Nephrol Dial Transplant. 1989;4(4):262-5. doi: 10.1093/oxfordjournals.ndt.a091869.
The difficulty of diagnosing Alport-type nephritis, and the possibility of altered antigenicity of the glomerular basement membrane in Alport-type nephritis is discussed. Attention is focused on the monoclonal antibody MCA-Pl as a specific tool in studying the Goodpasture antigenetic determinant in renal biopsy specimens. The clinical details and the results of MCA-Pl binding studies for three patients with nail patella syndrome are presented. Two of these patients proved to have an abnormal antigenicity of the glomerular basement membrane as demonstrated by the absence of binding of MCA-Pl. This is the first time that such an abnormality has been demonstrated in patients other than those with Alport-type nephritis. The significance of these results is discussed.
本文讨论了诊断奥尔波特型肾炎的困难，以及奥尔波特型肾炎中肾小球基底膜抗原性改变的可能性。重点关注单克隆抗体MCA-Pl作为研究肾活检标本中Goodpasture抗原决定簇的特异性工具。本文介绍了三名指甲髌骨综合征患者的临床细节及MCA-Pl结合研究结果。其中两名患者经证实肾小球基底膜抗原性异常，表现为MCA-Pl未结合。这是首次在奥尔波特型肾炎以外的患者中证实存在此类异常。本文还讨论了这些结果的意义。
