Curtis J J, Bhathena D, Leach R P, Galla J H, Lucas B A, Luke R G
Am J Med. 1976 Sep;61(3):401-6. doi: 10.1016/0002-9343(76)90378-8.
A patient with the nail-patella syndrome in whom end-stage renal failuure developed as the result of Goodpasture's syndrome is described. Lesions characteristic of both rare diseases were seen on renal morphology. It is postulated that the glomerular membrane alteration of the nail-patella syndrome predisposed to the development of antiglomerular basement membrane antibody and hence Goodpasture's syndrome. A review of the incidence of renal failure in the nail-patella syndrome suggests that renal involvement can no longer be regarded as benign and that immune mechanisms may be related to progressive renal disease in some cases.
本文描述了一名患有指甲-髌骨综合征的患者，其终末期肾衰竭是由Goodpasture综合征所致。在肾脏形态学上可见这两种罕见疾病的特征性病变。据推测，指甲-髌骨综合征的肾小球膜改变易引发抗肾小球基底膜抗体的产生，进而导致Goodpasture综合征。对指甲-髌骨综合征中肾衰竭发病率的综述表明，肾脏受累不能再被视为良性，并且在某些情况下免疫机制可能与进行性肾脏疾病相关。
