Theralogics, Inc., 1829 E. Franklin Street, Chapel Hill, NC 27514-5861, USA.
School of Dentistry, University of Alberta, 7020 Katz Group Centre, Edmonton, AB, Canada T6G 2R3.
J Immunol Res. 2014;2014:103780. doi: 10.1155/2014/103780. Epub 2014 Jan 19.
The β2-adrenergic receptor (β2AR) is a seven-transmembrane (7TM) G-protein coupled receptor that is expressed on cells of the pulmonary, cardiac, skeletal muscle, and immune systems. Previous work has shown that stimulation of this receptor on immune cells has profound effects on the regulatory activity of both adaptive and innate immune cells. This review examines the functional dichotomy associated with stimulation of β2AR and microglial cells. As well, recent studies targeting these receptors with long-acting agonists are considered with respect to their therapeutic potential in management of Parkinsonμs disease.
β2-肾上腺素能受体(β2AR)是一种七次跨膜(7TM)G 蛋白偶联受体,存在于肺部、心脏、骨骼肌和免疫系统的细胞上。先前的研究表明,刺激免疫细胞上的这种受体对适应性和固有免疫细胞的调节活性有深远的影响。这篇综述检查了与β2AR 和小胶质细胞刺激相关的功能二分法。此外,还考虑了针对这些受体的长效激动剂的最新研究,以评估其在帕金森病治疗中的潜在作用。