肯尼迪病的关键在肌肉。
Muscle matters in Kennedy's disease.
机构信息
Neurogenetics Branch, National Institute for Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA.
Neurogenetics Branch, National Institute for Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA; Department of Cell and Molecular Biology, Karolinska Institute, 17177 Stockholm, Sweden.
出版信息
Neuron. 2014 Apr 16;82(2):251-3. doi: 10.1016/j.neuron.2014.04.005.
Abstract
Polyglutamine expansion in the androgen receptor causes Kennedy's disease. Two recent reports, Cortes et al. (2014) in this issue of Neuron and Lieberman et al. (2014) in Cell Reports, raise the possibility that targeting expression of the mutant protein in skeletal muscle, instead of the nervous system, may mitigate manifestations of this disorder.
摘要
雄激素受体中的多聚谷氨酰胺扩展导致肯尼迪病。最近的两项研究报告，Cortes 等人（2014）在本期《神经元》和 Lieberman 等人（2014）在《细胞报告》中的研究结果提出了这样一种可能性，即针对骨骼肌中突变蛋白的表达，而不是神经系统，可能会减轻这种疾病的表现。
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