Hori Yoshiki, Itagaki Ryohei, Iwata Hideyuki, Maekawa Suguru
Dept. of Surgery, Shinkatsushika Hospital.
Gan To Kagaku Ryoho. 2014 Feb;41(2):245-8.
We report a case of a patient with unresectable gastric cancer who showed complete response(CR)to S-1 and paclitaxel (PTX)combination therapy. The patient(a 67-year-old woman)was diagnosed with unresectable advanced gastric cancer with metastases in the Virchow's lymph nodes and para-aortic lymph nodes. Systemic chemotherapy with 70mg/m2 S-1 (days 1-14)and 70mg/m2 PTX(day 1)was administered every 3 weeks. At the end of 7 courses of chemotherapy, the primary lesion and swollen lymph nodes became markedly smaller. After 7 courses, an additional 39 courses were administered over 2.5 years. No notable adverse events were seen, and the patient's performance status(PS)was 0. CR was monitored by imaging studies. No cancer cells were detected on cytological examination of the primary lesion. Monotherapy with 70mg/m2 S-1(days 1-28, 2-week drug holiday)has been administered for the past 3 years. The patient is currently treated as an outpatient and maintains CR and a PS of 0.
我们报告了一例不可切除胃癌患者，其对S-1与紫杉醇（PTX）联合治疗表现出完全缓解（CR）。该患者（一名67岁女性）被诊断为伴有魏尔啸淋巴结和腹主动脉旁淋巴结转移的不可切除晚期胃癌。每3周给予70mg/m² S-1（第1 - 14天）和70mg/m² PTX（第1天）进行全身化疗。在7个疗程化疗结束时，原发灶和肿大淋巴结明显缩小。7个疗程后，在2.5年期间又给予了39个疗程。未观察到明显不良事件，患者的体能状态（PS）为0。通过影像学检查监测CR情况。对原发灶进行细胞学检查未检测到癌细胞。在过去3年中一直给予70mg/m² S-1单药治疗（第1 - 28天，2周停药期）。该患者目前作为门诊患者接受治疗，维持CR状态且PS为0。
