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mFOLFOX6联合帕尼单抗新辅助化疗后可治愈性切除的乙状结肠癌1例

[A case of curatively resected sigmoid colon cancer after mFOLFOX6 plus panitumumab neoadjuvant chemotherapy].

作者信息

Yoshikawa Kiyoshi, Kuwata Hirofumi, Nakahata Yoshikatsu

机构信息

Dept. of General Surgery, Neyagawa Ikuno Hospital.

出版信息

Gan To Kagaku Ryoho. 2014 Mar;41(3):399-401.

Abstract

A 54-year-old man with residual urine, abdominal pain, and a high fever was diagnosed with KRAS wild-type sigmoid colon cancer with urinary bladder invasion. Considering the difficulty of curative resection, we first performed an ileostomy. Remarkable tumor regression was indicated by computed tomography(CT)and colonoscopy after 3 courses of mFOLFOX6 plus panitumumab. A sigmoidectomy and partial cystectomy were performed with a curative intent. Six courses of XELOX adjuvant chemotherapy were administered, and no recurrence has been observed for 9 months. mFOLFOX6 plus panitumumab might be an effective preoperative chemotherapy for patients with locally advanced KRAS wild-type colon cancer.

摘要

一名54岁男性,伴有残余尿、腹痛和高热,被诊断为KRAS野生型乙状结肠癌伴膀胱侵犯。考虑到根治性切除的难度,我们首先进行了回肠造口术。在接受3个疗程的mFOLFOX6联合帕尼单抗治疗后,计算机断层扫描(CT)和结肠镜检查显示肿瘤明显消退。遂行乙状结肠切除术和部分膀胱切除术,目的是根治。给予6个疗程的XELOX辅助化疗,9个月来未观察到复发。mFOLFOX6联合帕尼单抗可能是局部晚期KRAS野生型结肠癌患者有效的术前化疗方案。

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