Yoshikawa Kiyoshi, Kuwata Hirofumi, Nakahata Yoshikatsu
Dept. of General Surgery, Neyagawa Ikuno Hospital.
Gan To Kagaku Ryoho. 2014 Mar;41(3):399-401.
A 54-year-old man with residual urine, abdominal pain, and a high fever was diagnosed with KRAS wild-type sigmoid colon cancer with urinary bladder invasion. Considering the difficulty of curative resection, we first performed an ileostomy. Remarkable tumor regression was indicated by computed tomography(CT)and colonoscopy after 3 courses of mFOLFOX6 plus panitumumab. A sigmoidectomy and partial cystectomy were performed with a curative intent. Six courses of XELOX adjuvant chemotherapy were administered, and no recurrence has been observed for 9 months. mFOLFOX6 plus panitumumab might be an effective preoperative chemotherapy for patients with locally advanced KRAS wild-type colon cancer.
一名54岁男性，伴有残余尿、腹痛和高热，被诊断为KRAS野生型乙状结肠癌伴膀胱侵犯。考虑到根治性切除的难度，我们首先进行了回肠造口术。在接受3个疗程的mFOLFOX6联合帕尼单抗治疗后，计算机断层扫描（CT）和结肠镜检查显示肿瘤明显消退。遂行乙状结肠切除术和部分膀胱切除术，目的是根治。给予6个疗程的XELOX辅助化疗，9个月来未观察到复发。mFOLFOX6联合帕尼单抗可能是局部晚期KRAS野生型结肠癌患者有效的术前化疗方案。
