Kikuchi Yasuka, Oyama-Manabe Noriko, Naya Masanao, Manabe Osamu, Tomiyama Yuuki, Sasaki Tsukasa, Katoh Chietsugu, Kudo Kohsuke, Tamaki Nagara, Shirato Hiroki
Department of Diagnostic and Interventional Radiology, Hokkaido University Hospital, Kita15, Nishi 7, kita-ku, Sapporo, 060-8638, Japan.
Eur Radiol. 2014 Jul;24(7):1547-56. doi: 10.1007/s00330-014-3164-3. Epub 2014 Apr 18.
This study introduces a method to calculate myocardium blood flow (MBF) and coronary flow reserve (CFR) using the relatively low-dose dynamic 320-row multi-detector computed tomography (MDCT), validates the method against (15)O-H₂O positron-emission tomography (PET) and assesses the CFRs of coronary artery disease (CAD) patients.
Thirty-two subjects underwent both dynamic CT perfusion (CTP) and PET perfusion imaging at rest and during pharmacological stress. In 12 normal subjects (pilot group), the calculation method for MBF and CFR was established. In the other 13 normal subjects (validation group), MBF and CFR obtained by dynamic CTP and PET were compared. Finally, the CFRs obtained by dynamic CTP and PET were compared between the validation group and CAD patients (n = 7).
Correlation between MBF of MDCT and PET was strong (r = 0.95, P < 0.0001). CFR showed good correlation between dynamic CTP and PET (r = 0.67, P = 0.0126). CFRCT in the CAD group (2.3 ± 0.8) was significantly lower than that in the validation group (5.2 ± 1.8) (P = 0.0011).
We established a method for measuring MBF and CFR with the relatively low-dose dynamic MDCT. Lower CFR was well demonstrated in CAD patients by dynamic CTP.
• MBF and CFR can be calculated using dynamic CTP with 320-row MDCT. • MBF and CFR showed good correlation between dynamic CTP and PET. • Lower CFR was well demonstrated in CAD patients by dynamic CTP.
本研究介绍一种使用相对低剂量的动态320排多探测器计算机断层扫描（MDCT）计算心肌血流量（MBF）和冠状动脉血流储备（CFR）的方法，将该方法与（15）O-H₂O正电子发射断层扫描（PET）进行验证，并评估冠状动脉疾病（CAD）患者的CFR。
32名受试者在静息和药物负荷状态下均接受了动态CT灌注（CTP）和PET灌注成像。在12名正常受试者（试验组）中，建立了MBF和CFR的计算方法。在另外13名正常受试者（验证组）中，比较了动态CTP和PET获得的MBF和CFR。最后，比较了验证组和CAD患者（n = 7）通过动态CTP和PET获得的CFR。
MDCT的MBF与PET之间相关性很强（r = 0.95，P < 0.0001）。CFR在动态CTP和PET之间显示出良好的相关性（r = 0.67，P = 0.0126）。CAD组的CFRCT（2.3±0.8）显著低于验证组（5.2±1.8）（P = 0.0011）。
我们建立了一种使用相对低剂量动态MDCT测量MBF和CFR的方法。通过动态CTP在CAD患者中很好地显示出较低的CFR。
• 可使用320排MDCT的动态CTP计算MBF和CFR。• 动态CTP和PET之间的MBF和CFR显示出良好的相关性。• 通过动态CTP在CAD患者中很好地显示出较低的CFR。
