同源异型基因CDX2在胃癌中的功能及定位新见解。
New insights into the functions and localization of the homeotic gene CDX2 in gastric cancer.
作者信息
Yan Lin-Hai, Wei Wei-Yuan, Xie Yu-Bo, Xiao Qiang
机构信息
Lin-Hai Yan, Wei-Yuan Wei, Qiang Xiao, Department of Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning 530021, Guangxi Zhuang Autonomous Region, China.
出版信息
World J Gastroenterol. 2014 Apr 14;20(14):3960-6. doi: 10.3748/wjg.v20.i14.3960.
Abstract
Gastric cancer is one of the most frequent cancers, and it ranks the third most common cancer in China. The most recently caudal-related homeobox transcription factor 2 (CDX2) is expressed in a large number of human gastrointestinal cancers. In addition, gastric epithelial cell mutations in CDX2 result in tumor promotion, which is characterized by cellular drug resistance and a high proclivity for developing cancer. A series of publications over the past years suggests a mechanism by which CDX2 overexpression results in multidrug resistance. CDX2 appears to forward control regenerating IV and the multidrug resistance 1 expression signaling pathway for regulation of cell drug resistance.
摘要
胃癌是最常见的癌症之一，在中国它是第三大常见癌症。最近发现尾型相关同源盒转录因子2（CDX2）在大量人类胃肠道癌症中表达。此外，CDX2中的胃上皮细胞突变会促进肿瘤生长，其特征是细胞耐药性和高癌症发展倾向。过去几年的一系列出版物提出了一种CDX2过表达导致多药耐药的机制。CDX2似乎正向调控再生IV和多药耐药1表达信号通路以调节细胞耐药性。
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