Tezel Ahmet, Demir Muzaffer
Trakya University, School of Medicine, Department of Gastroenterology, Edirne, Turkey.
Trakya University, School of Medicine, Department of Hematology, Edirne, Turkey.
Turk J Haematol. 2012 Jun;29(2):111-9. doi: 10.5505/tjh.2012.04557. Epub 2012 Jun 5.
Inflammatory Bowel Disease (IBD) is a group of chronic and relapsing inflammatory disorders of the gastrointestinalsystem. In these cases, findings are detected in extraintestinal systems also. There is a tendency for thrombotic eventsin IBD, as in the other inflammatory processes. The pathogenesis of this thrombotic tendency is multidimensional,including lack of natural anticoagulants, prothrombotic media induced via the inflammatory process, long-termsedentary life style, steroid use, surgery, and catheter placement. The aim of this review was to highlight the positiverelationship between IBD and thrombotic events, and the proper treatment of at-risk patients.
炎症性肠病(IBD)是一组胃肠道的慢性复发性炎症性疾病。在这些病例中,还可在肠外系统中发现相关表现。与其他炎症过程一样,IBD患者存在血栓形成事件的倾向。这种血栓形成倾向的发病机制是多方面的,包括天然抗凝剂缺乏、炎症过程诱导的促血栓介质、长期久坐的生活方式、使用类固醇、手术以及放置导管等。本综述的目的是强调IBD与血栓形成事件之间的正相关关系,以及对高危患者的恰当治疗。