Alotaibi Abdullah, Alhubayshi Abrar, Allehibi Abed, Almtawa Abdullah, Alotaibi Nawaf, Alghamdi Adel, Alrajhi Saad, Alqutub Adel, Aleid Ahmad, Alamr Abdulrhman, Ibrahim Bashaar, Alahmari Mohammed, Alhamidi Hussam, Ahmad Shameem, AlBayyat Hadeel, Alshaya Osama, Altannir Youssef, Alghamdi Ahmed
Department of Gastroenterology and Hepatology, Riyadh, Saudi Arabia.
Department of Internal Medicine, King Fahad Medical City, Riyadh, Saudi Arabia.
Saudi J Med Med Sci. 2024 Apr-Jun;12(2):169-174. doi: 10.4103/sjmms.sjmms_139_23. Epub 2024 Apr 5.
Patients with inflammatory bowel disease (IBD) may also experience extraintestinal manifestations (EIMs), which can affect various organ systems, and their occurrence is based on disease activity.
To determine the prevalence of EIMs and their most common types among IBD patients from Saudi Arabia.
This retrospective study included all IBD patients aged 14-80 years who visited the Gastroenterology and Hepatology clinics at King Fahad Medical City, Riyadh, between February 2017 and December 2022. The collected data included demographic characteristics, disease characteristics, EIMs, and treatment.
The study included 578 IBD patients, of which 65 (11.2%) had at least one EIM, with primary sclerosing cholangitis (46.2%) and sacroiliitis (16.9%) being the most common. Patients with ulcerative colitis were more likely to have EIMs than those with Crohn's disease (15.1% vs. 9%; = 0.026). Patients with ileocolonic (L3) Crohn's disease reported a higher prevalence of EIMs (7.5%) than those with other disease locations ( = 0.012), while in patients with ulcerative colitis, those with extensive colitis (E3) reported higher prevalence of EIMs (19.2%) ( = 0.001). Patients receiving 6 MP had a significantly high prevalence of EIMs ( = 0.014).
The prevalence of extraintestinal manifestations among IBD patients in Saudi Arabia is 11.2%. These findings suggest the need for clinicians to screen for EIMs and manage them early. Further research is needed to understand the mechanisms underlying EIMs for the development of more effective treatments.
炎症性肠病（IBD）患者也可能出现肠外表现（EIMs），其可影响多个器官系统，且其发生基于疾病活动情况。
确定沙特阿拉伯IBD患者中EIMs的患病率及其最常见类型。
这项回顾性研究纳入了2017年2月至2022年12月期间在利雅得法赫德国王医疗城胃肠病学和肝病科就诊的所有14至80岁的IBD患者。收集的数据包括人口统计学特征、疾病特征、EIMs和治疗情况。
该研究纳入了578例IBD患者，其中65例（11.2%）至少有一种EIM，原发性硬化性胆管炎（46.2%）和骶髂关节炎（16.9%）最为常见。溃疡性结肠炎患者比克罗恩病患者更易出现EIMs（15.1%对9%；P = 0.026）。回结肠型（L3）克罗恩病患者的EIMs患病率（7.5%）高于其他疾病部位的患者（P = 0.012），而在溃疡性结肠炎患者中，广泛性结肠炎（E3）患者的EIMs患病率更高（19.2%）（P = 0.001）。接受6-巯基嘌呤治疗的患者EIMs患病率显著较高（P = 0.014）。
沙特阿拉伯IBD患者中肠外表现的患病率为11.2%。这些发现表明临床医生需要筛查EIMs并尽早进行管理。需要进一步研究以了解EIMs的潜在机制，从而开发更有效的治疗方法。
