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5-HT2B 受体诱导的新生小鸡日龄内的糖原分解介导的 5-羟色胺对早期记忆形成的调节作用。

Serotonin mediation of early memory formation via 5-HT2B receptor-induced glycogenolysis in the day-old chick.

机构信息

Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University Parkville, VIC, Australia.

Department of Clinical Pharmacology, China Medical University Shenyang, China.

出版信息

Front Pharmacol. 2014 Apr 1;5:54. doi: 10.3389/fphar.2014.00054. eCollection 2014.

DOI:10.3389/fphar.2014.00054
PMID:24744730
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3978258/
Abstract

Investigation of the effects of serotonin on memory formation in the chick revealed an action on at least two 5-HT receptors. Serotonin injected intracerebrally produced a biphasic effect on memory consolidation with enhancement at low doses and inhibition at higher doses. The non-selective 5-HT receptor antagonist methiothepin and the selective 5-HT2B/C receptor antagonist SB221284 both inhibited memory, suggesting actions of serotonin on at least two different receptor subtypes. The 5-HT2B/C and astrocyte-specific 5-HT receptor agonist, fluoxetine and paroxetine, enhanced memory and the effect was attributed to glycogenolysis. Inhibition of glycogenolysis with a low dose of DAB (1,4-dideoxy-1,4-imino-D-arabinitol) prevented both serotonin and fluoxetine from enhancing memory during short-term memory but not during intermediate memory. The role of serotonin on the 5-HT2B/C receptor appears to involve glycogen breakdown in astrocytes during short-term memory, whereas other published evidence attributes the second period of glycogenolysis to noradrenaline.

摘要

研究发现，5-羟色胺对小鸡记忆形成的影响至少作用于两种 5-HT 受体。脑室内注射 5-羟色胺对记忆巩固产生双相作用，低剂量增强，高剂量抑制。非选择性 5-HT 受体拮抗剂甲硫哒嗪和选择性 5-HT2B/C 受体拮抗剂 SB221284 均抑制记忆，提示 5-羟色胺至少作用于两种不同的受体亚型。5-HT2B/C 和星形胶质细胞特异性 5-HT 受体激动剂氟西汀和帕罗西汀增强记忆，作用归因于糖原分解。用低剂量 DAB（1,4-二脱氧-1,4-亚氨基-D-阿拉伯糖醇）抑制糖原分解可阻止 5-羟色胺和氟西汀在短期记忆中增强记忆，但在中期记忆中无此作用。5-羟色胺对 5-HT2B/C 受体的作用似乎涉及短期记忆中星形胶质细胞中的糖原分解，而其他已发表的证据将第二次糖原分解归因于去甲肾上腺素。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8218/3978258/3b2a609b8080/fphar-05-00054-g008.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8218/3978258/2487d0b44749/fphar-05-00054-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8218/3978258/3b2a609b8080/fphar-05-00054-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8218/3978258/d387c42db2af/fphar-05-00054-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8218/3978258/923a4b002507/fphar-05-00054-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8218/3978258/31d3641870b2/fphar-05-00054-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8218/3978258/295242623ab9/fphar-05-00054-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8218/3978258/4f4f544dd6ac/fphar-05-00054-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8218/3978258/b61170df2eb6/fphar-05-00054-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8218/3978258/2487d0b44749/fphar-05-00054-g007.jpg
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