Guazzaroni M, Tosti D, Rascioni M, Mataloni M, Citraro D, Simonetti G
Department of Diagnostic Imaging, Molecular Imaging, Interventional Radiology and Radiation Therapy, University Hospital Tor Vergata, Viale Oxford, 81-00133 Rome, Italy.
Case Rep Oncol Med. 2014;2014:961675. doi: 10.1155/2014/961675. Epub 2014 Mar 12.
Uterine leiomyosarcoma (ULMS) is an uncommon malignancy that accounts for one-third of uterine sarcomas and represents 1% of all uterine malignancies, with an incidence averaging 0.5-1/100,000/year. The prognosis is poor due to its intrinsic aggressiveness and its characteristic high metastatic potential with reported distant metastatic spread in lung, abdomen, soft tissue, and brain. We present the case of a 67-year-old woman with lung metastasis after eighteen years since uterine leiomyosarcoma diagnosis and its following surgical resection. The diagnosis of pulmonary metastases was obtained by reviewing the histology of the previous uterine tumor: the tumor cells were immunoreactive for CD10, PR, and smooth muscle actin (SMA), but negative for desmin, S100, CD34, CD 117, cytokeratins AE1AE3, CD68R, and ER. To our knowledge, this disease-free interval is the longest among previous reports of pulmonary metastasis of uterine leiomyosarcoma.
子宫平滑肌肉瘤（ULMS）是一种罕见的恶性肿瘤，占子宫肉瘤的三分之一，占所有子宫恶性肿瘤的1%，年发病率平均为0.5-1/100,000。由于其内在的侵袭性和高转移潜能，其预后较差，据报道可远处转移至肺、腹部、软组织和脑。我们报告一例67岁女性，在子宫平滑肌肉瘤诊断并手术切除18年后发生肺转移。通过回顾先前子宫肿瘤的组织学检查确诊为肺转移：肿瘤细胞对CD10、PR和平滑肌肌动蛋白（SMA）呈免疫反应，但对结蛋白、S100、CD34、CD117、细胞角蛋白AE1AE3、CD68R和ER呈阴性。据我们所知，在先前子宫平滑肌肉瘤肺转移的报道中，这个无病间期是最长的。
