Mishra Pritinanda, Jacob Sajini Elizabeth, Basu Debdatta, Panigrahi Manoj Kumar, Govindaraj Vishnukanth
Department of Pathology, Jawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry 605006, India.
Department of Pulmonary Medicine, Jawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry, India.
Case Rep Pathol. 2014;2014:561861. doi: 10.1155/2014/561861. Epub 2014 Mar 16.
Silicosis is an occupational lung disease caused by inhalation of crystalline silica. People working in occupations like sandblasting, surface drilling, tunneling, silica flour milling, ceramic making, and so forth are predisposed to develop silicosis. Crystalline forms of silica are more fibrogenic than the amorphous forms, highlighting the importance of the physical form in pathogenesis. Lung biopsy is rarely performed for the diagnosis of silicosis as it can easily be detected by occupational history and radiological features. Patients with silicosis can develop complications like tuberculosis, lung cancer, progressive massive fibrosis, cor pulmonale, broncholithiasis, or tracheobronchial compression by lymph nodes. Pleural involvement in silicosis is rare. Spontaneous pneumothorax is a pleural complication that can develop in such patients. Usually in silicosis pneumothorax is unilateral. We hereby report the lung biopsy findings and discuss the mechanism of pneumothorax development in a case of chronic silicosis who, later on died during the course of the disease.
矽肺是一种因吸入结晶二氧化硅而引起的职业性肺病。从事喷砂、露天钻探、隧道挖掘、硅粉研磨、陶瓷制造等职业的人易患矽肺。结晶形式的二氧化硅比无定形形式更具致纤维化性,这突出了物理形态在发病机制中的重要性。由于根据职业史和放射学特征很容易诊断出矽肺,因此很少通过肺活检来诊断。矽肺患者可能会出现诸如肺结核、肺癌、进行性大块纤维化、肺心病、支气管结石症或淋巴结压迫气管支气管等并发症。矽肺累及胸膜的情况很少见。自发性气胸是这类患者可能出现的一种胸膜并发症。通常,矽肺患者的气胸为单侧性。我们在此报告一例慢性矽肺患者的肺活检结果,并讨论气胸发生的机制,该患者后来在病程中死亡。