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致命尘埃:硅肺结核——印度尼西亚一种被低估和忽视的致命疾病

Deadly dust: Silicotuberculosis as a downplayed and overlooked fatal disease in Indonesia.

作者信息

Djatioetomo Yovita Citra Eka Dewi, Marhana Isnin Anang

机构信息

Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Airlangga - Dr. Soetomo General Academic Hospital, Surabaya, Indonesia.

出版信息

Ann Med Surg (Lond). 2022 May 17;78:103794. doi: 10.1016/j.amsu.2022.103794. eCollection 2022 Jun.

Abstract

BACKGROUND

Silicosis is one of the most common diseases among all occupational diseases. The main clinical focus on the silicosis complication will be tuberculosis.

CASE PRESENTATION

A 28-year-old male presented with complaints of chronic dry cough, weight loss, decreased appetite, and night sweats. The patient worked in the synthetic leather factory for 7 years and rarely used proper protective equipment. Chest X-ray showed bilateral fibroinfiltrate as a sign of a specific process in the lungs. Thoracic HRCT suggested an infected cystic type of bronchiectasis. Bronchoalveolar lavage from bronchoscopy was performed. The result of the silica spectrophotometric test and GenXpert BAL was both positive for silicosis and tuberculosis, consecutively. The patient has been diagnosed with an occupational lung disease accompanied by tuberculosis complications, namely silicotuberculosis. The patient received tuberculosis therapy and was advised to an early retirement due to disability.

DISCUSSION

The duration and level of intensity of exposure, as well as the severity of silicosis, are factors of tuberculosis. The silicosis diagnosis can be made from occupational history or silica exposure, as well as appropriate radiological and histopathological findings.

CONCLUSION

Silicotuberculosis is a disease due to silica exposure, and is often found in TB endemic countries.

摘要

背景

矽肺是所有职业病中最常见的疾病之一。矽肺并发症的主要临床关注点是肺结核。

病例介绍

一名28岁男性,主诉慢性干咳、体重减轻、食欲减退和盗汗。该患者在合成皮革厂工作7年,很少使用适当的防护设备。胸部X线显示双侧纤维浸润,这是肺部特定病变的迹象。胸部高分辨率CT提示感染性囊状支气管扩张。进行了支气管镜下的支气管肺泡灌洗。二氧化硅分光光度法检测结果和GeneXpert支气管肺泡灌洗结果均依次显示矽肺和肺结核呈阳性。该患者被诊断为患有伴有肺结核并发症的职业性肺病,即矽肺结核。患者接受了抗结核治疗,并因残疾被建议提前退休。

讨论

接触的持续时间和强度水平以及矽肺的严重程度是患肺结核的因素。矽肺的诊断可根据职业史或二氧化硅接触情况以及适当的放射学和组织病理学检查结果做出。

结论

矽肺结核是一种因接触二氧化硅而引起的疾病,在结核病流行国家经常发现。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/35f1/9207042/f20164daaf24/gr1.jpg

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