缺氧与肿瘤相关巨噬细胞：支持肿瘤进展的致命联盟。
Hypoxia and tumor-associated macrophages: A deadly alliance in support of tumor progression.
作者信息
Van Overmeire Eva, Laoui Damya, Keirsse Jiri, Van Ginderachter Jo A
机构信息
Lab of Cellular and Molecular Immunology; Vrije Universiteit Brussel; Brussels, Belgium ; Myeloid Cell Immunology Lab; VIB; Brussels, Belgium.
出版信息
Oncoimmunology. 2014 Jan 1;3(1):e27561. doi: 10.4161/onci.27561. Epub 2014 Jan 3.
Abstract
Tumor-associated macrophages (TAMs) provide a significant contribution to tumor growth and metastasis. We demonstrated the existence of two main TAM subsets, differing in activation state and localization. Of these, M2-like TAMs reside in hypoxic regions of the tumor mass and can be used as targets for hypoxia tracers. This said, hypoxia does not regulate the differentiation of TAMs but finely tunes the activity of the M2-like population.
摘要
肿瘤相关巨噬细胞（TAM）对肿瘤生长和转移起着重要作用。我们证明了存在两种主要的TAM亚群，它们在激活状态和定位上有所不同。其中，M2样TAM存在于肿瘤块的缺氧区域，可作为缺氧示踪剂的靶点。也就是说，缺氧并不调节TAM的分化，而是精细调节M2样群体的活性。
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本文引用的文献
1
Tumor hypoxia does not drive differentiation of tumor-associated macrophages but rather fine-tunes the M2-like macrophage population.
Cancer Res. 2014 Jan 1;74(1):24-30. doi: 10.1158/0008-5472.CAN-13-1196. Epub 2013 Nov 12.
2
Influence of tumour micro-environment heterogeneity on therapeutic response.
Nature. 2013 Sep 19;501(7467):346-54. doi: 10.1038/nature12626.
3
Prognostic significance of tumor-associated macrophages in solid tumor: a meta-analysis of the literature.
PLoS One. 2012;7(12):e50946. doi: 10.1371/journal.pone.0050946. Epub 2012 Dec 28.
4
Nanobody-based targeting of the macrophage mannose receptor for effective in vivo imaging of tumor-associated macrophages.
Cancer Res. 2012 Aug 15;72(16):4165-77. doi: 10.1158/0008-5472.CAN-11-2994. Epub 2012 Jun 19.
5
Molecular imaging of hypoxia.
J Nucl Med. 2011 Feb;52(2):165-8. doi: 10.2967/jnumed.110.075663. Epub 2011 Jan 13.
6
Imaging cycling tumor hypoxia.
Cancer Res. 2010 Dec 15;70(24):10019-23. doi: 10.1158/0008-5472.CAN-10-2821.
7
Different tumor microenvironments contain functionally distinct subsets of macrophages derived from Ly6C(high) monocytes.
Cancer Res. 2010 Jul 15;70(14):5728-39. doi: 10.1158/0008-5472.CAN-09-4672. Epub 2010 Jun 22.
8
Macrophage diversity enhances tumor progression and metastasis.
Cell. 2010 Apr 2;141(1):39-51. doi: 10.1016/j.cell.2010.03.014.
9
Heterozygous deficiency of PHD2 restores tumor oxygenation and inhibits metastasis via endothelial normalization.
Cell. 2009 Mar 6;136(5):839-851. doi: 10.1016/j.cell.2009.01.020. Epub 2009 Feb 12.
10
Mechanisms regulating the recruitment of macrophages into hypoxic areas of tumors and other ischemic tissues.
Blood. 2004 Oct 15;104(8):2224-34. doi: 10.1182/blood-2004-03-1109. Epub 2004 Jul 1.
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