PAQR-2可能是冷适应过程中膜流动性的调节因子。
PAQR-2 may be a regulator of membrane fluidity during cold adaptation.
作者信息
Pilon Marc, Svensk Emma
机构信息
Department of Chemistry and Molecular Biology; University of Gothenburg; Medicinaregatan 9C; Gothenburg, Sweden.
出版信息
Worm. 2013 Oct 1;2(4):e27123. doi: 10.4161/worm.27123. Epub 2013 Nov 19.
Abstract
PAQR-2 is a C. elegans homolog of the mammalian adiponectin receptors. We have recently shown that PAQR-2 is essential for the ability of C. elegans to grow at its lower temperature range, i.e., 15 °C, and that the likely role of PAQR-2 during cold adaptation is to regulate membrane fluidity by promoting fatty acid desaturation. Here we present a summary of this work, with an emphasis on placing our C. elegans findings in the context of mammalian biology.
摘要
PAQR-2是哺乳动物脂联素受体在秀丽隐杆线虫中的同源物。我们最近发现，PAQR-2对于秀丽隐杆线虫在较低温度范围（即15°C）下生长的能力至关重要，并且PAQR-2在冷适应过程中的可能作用是通过促进脂肪酸去饱和来调节膜流动性。在此，我们总结这项工作，重点是将我们在秀丽隐杆线虫中的发现置于哺乳动物生物学的背景下。
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