Department of Biotechnology, University of Verona, 37134 Verona, Italy.
Biomed Res Int. 2014;2014:136419. doi: 10.1155/2014/136419. Epub 2014 Mar 12.
In recent years, the production of recombinant pharmaceutical proteins in heterologous systems has increased significantly. Most applications involve complex proteins and glycoproteins that are difficult to produce, thus promoting the development and improvement of a wide range of production platforms. No individual system is optimal for the production of all recombinant proteins, so the diversity of platforms based on plants offers a significant advantage. Here, we discuss the production of four recombinant pharmaceutical proteins using different platforms, highlighting from these examples the unique advantages of plant-based systems over traditional fermenter-based expression platforms.
近年来，异源系统中重组药物蛋白的生产显著增加。大多数应用涉及难以生产的复杂蛋白质和糖蛋白，从而促进了广泛的生产平台的发展和改进。没有一个单一的系统对所有重组蛋白的生产都是最优的，因此基于植物的平台多样性具有显著的优势。在这里，我们讨论了使用不同平台生产四种重组药物蛋白的情况，从这些例子中突出了植物基系统相对于传统发酵器表达平台的独特优势。
