Nowak Witold Norbert, Florczyk Urszula, Józkowicz Alicja, Dulak Józef
Postepy Biochem. 2013;59(4):405-14.
Endothelium has an immense impact on the tissue regeneration, regulation of atherosclerosis and tumour growth. Therefore, modification of endothelial cell differentiation and function seems a promising target for many therapies. MicroRNAs are small RNA molecules, which recognize and inhibit specific mRNAs. In that way, they can regulate and orchestrate whole signalling pathways. It has been shown that microRNAs can fine-tune endothelial cell functions since they have either pro- and antiangiogenic activity, regulate expression of e.g. adhesion molecules or nitric oxide synthase. Furthermore, microRNAs modulate differentiation of embryonic stem cells to endothelial cells and their further specialization towards specific vascular bed. This review focuses mainly on the influence of microRNA on the angiogenesis and endothelial cell differentiation.
内皮细胞对组织再生、动脉粥样硬化调节及肿瘤生长具有巨大影响。因此，修饰内皮细胞分化和功能似乎是许多治疗方法的一个有前景的靶点。微小RNA是小RNA分子，可识别并抑制特定mRNA。通过这种方式，它们能够调节并协调整个信号通路。研究表明，微小RNA可微调内皮细胞功能，因为它们具有促血管生成和抗血管生成活性，可调节如黏附分子或一氧化氮合酶等的表达。此外，微小RNA可调节胚胎干细胞向内皮细胞的分化及其向特定血管床的进一步特化。本综述主要关注微小RNA对血管生成和内皮细胞分化的影响。
