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前列腺素 E2：流感病毒宿主反应中的罪魁祸首。

Prostaglandin E2: the villain in the host response to influenza virus.

机构信息

Department of Microbiology and Immunobiology, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA.

Department of Microbiology and Immunobiology, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA.

出版信息

Immunity. 2014 Apr 17;40(4):453-4. doi: 10.1016/j.immuni.2014.03.008.

DOI:10.1016/j.immuni.2014.03.008
PMID:24745327
Abstract

Prostaglandins are lipid mediators that are involved in a plethora of biological processes. In this issue of Immunity, Coulombe et al. (2014) report that prostaglandin E2 suppresses innate and adaptive immune responses to influenza virus.

摘要

前列腺素是参与多种生物过程的脂类介质。在本期《免疫》杂志中，库隆等人（2014 年）报告称前列腺素 E2 抑制了对流感病毒的固有和适应性免疫反应。

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Prostaglandin E2: the villain in the host response to influenza virus.前列腺素 E2：流感病毒宿主反应中的罪魁祸首。
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MPGES-1-derived PGE2 suppresses CD80 expression on tumor-associated phagocytes to inhibit anti-tumor immune responses in breast cancer.MPGES-1衍生的前列腺素E2抑制肿瘤相关吞噬细胞上CD80的表达，从而抑制乳腺癌中的抗肿瘤免疫反应。
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