Ben-Zaken Sigal, Meckel Yoav, Nemet Dan, Eliakim Alon
The Zinman College of Physical Education and Sports Sciences at the Wingate Institute, Genetics and Molecular Biology Laboratory, Netanya, Israel.
Child Health and Sports Center, Pediatric Department, Meir Medical Center, Sackler School of Medicine, Tel-Aviv University, Israel.
J Sci Med Sport. 2015 May;18(3):323-7. doi: 10.1016/j.jsams.2014.03.007. Epub 2014 Mar 18.
To examine the prevalence of the Insulin-Like Growth Factor-I receptor (IGF-IR) 275124A>C polymorphism, known to be associated with exercise-related cardiac hypertrophy, among elite endurance and power athletes.
One hundred and fifty-nine athletes (118 men and 41 women, age: 35.9±12.2 yrs) participated in the study.
We hypothesized that presence of the A allele will be significantly more common among endurance athletes (n=77) compared to power athletes (n=82) and non-physically active controls (n=68). Athletes within each group were further divided according to their individual best performance into elite athletes (those who had represented the country in international track-and-field or triathlon competitions or in the Olympic Games) and national-level athletes.
The prevalence of the AA genotype was significantly higher (p<0.05) in the endurance athletes group (49%) compared to the power athletes group (33%), but did not differ from the control group (46%). There was no significant difference in the prevalence of the AA genotype between elite and national level endurance athletes (44% versus 52%, respectively). In contrast, among power athletes, the prevalence of the AA genotype was significantly lower in the elite compared to national level athletes (17% versus 42%, respectively; p<0.05).
The results of the present study may suggest that the IGF-IR AA polymorphism is beneficial for endurance-type sports, but is not associated with elite endurance performance. In contrast, the presence of the AA genotype may be a disadvantage in power sports. All together the results of the present study suggest that IGF-IR polymorphism may differentiate between the two edges of the endurance-power athletic performance spectrum.
研究胰岛素样生长因子-I受体（IGF-IR）275124A>C多态性在优秀耐力和力量型运动员中的流行情况，已知该多态性与运动相关的心脏肥大有关。
159名运动员（118名男性和41名女性，年龄：35.9±12.2岁）参与了该研究。
我们假设，与力量型运动员（n = 82）和非体育活动对照组（n = 68）相比，耐力型运动员（n = 77）中A等位基因的存在会显著更为常见。每组运动员根据其个人最佳成绩进一步分为优秀运动员（那些曾代表国家参加国际田径、铁人三项比赛或奥运会的运动员）和国家级运动员。
耐力型运动员组（49%）中AA基因型的流行率显著高于力量型运动员组（33%）（p<0.05），但与对照组（46%）无差异。优秀和国家级耐力型运动员之间AA基因型的流行率无显著差异（分别为44%和52%）。相反，在力量型运动员中，优秀运动员的AA基因型流行率显著低于国家级运动员（分别为17%和42%；p<0.05）。
本研究结果可能表明，IGF-IR AA多态性对耐力型运动有益，但与优秀耐力表现无关。相反，AA基因型的存在可能在力量型运动中是一个劣势。本研究的所有结果表明，IGF-IR多态性可能在耐力-力量运动表现谱的两个极端之间产生差异。
