局限于肥大细胞的四聚体形成类胰蛋白酶及其在止血和凝血中的有益作用。

Mast cell-restricted tetramer-forming tryptases and their beneficial roles in hemostasis and blood coagulation.

机构信息

Allergy Service, Hospital Universitario Gregorio Marañón, Instituto de Investigación Sanitaria Gregorio Marañón, Dr Esquerdo 46, Madrid 28007, Spain.

Division of Rheumatology, Immunology, and Allergy, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, 1 Jimmy Fund Way, Smith Building, Boston, MA 02115, USA.

出版信息

Immunol Allergy Clin North Am. 2014 May;34(2):263-81. doi: 10.1016/j.iac.2014.01.001. Epub 2014 Mar 15.

DOI:10.1016/j.iac.2014.01.001

PMID:24745673

Abstract

Tetramer-forming tryptase (hTryptase-β) was recently discovered to have a prominent role in preventing the internal accumulation of life-threatening fibrin deposits and fibrin-platelet clots. The anticoagulant activity of hTryptase-β is an explanation for the presence of hemorrhagic disorders in some patients with anaphylaxis or mastocytosis. The fragments of hFibrinogen formed by the proteolysis of this prominent protein by hTryptase-β could be used as biomarkers in the blood and/or urine for the identification and monitoring of patients with mast cell-dependent disorders. Recombinant hTryptase-β has potential to be used in clinical settings where it is desirable to inhibit blood coagulation.

摘要

四聚体形成的 tryptase（hTryptase-β）最近被发现具有显著作用，可防止危及生命的纤维蛋白沉积物和纤维蛋白-血小板血栓的内部积聚。hTryptase-β 的抗凝活性解释了一些过敏或肥大细胞病患者存在出血性疾病的原因。hTryptase-β 对这种主要蛋白的蛋白水解形成的 hFibrinogen 片段可作为血液和/或尿液中的生物标志物，用于鉴定和监测依赖肥大细胞的疾病患者。重组 hTryptase-β 具有在临床环境中使用的潜力，在这些环境中抑制血液凝固是理想的。