Section of Respiratory Medicine, Department of Pediatrics, Yale School of Medicine, New Haven, Connecticut.
Yale Center for Analytical Sciences, Yale School of Public Health, New Haven, Connecticut.
Ann Allergy Asthma Immunol. 2014 Jun;112(6):519-24. doi: 10.1016/j.anai.2014.03.017. Epub 2014 Apr 16.
Potential vitamin D-related influences on inflammatory diseases such as asthma are controversial, including the suggestion that vitamin D insufficiency is associated with increased asthma morbidity. Vitamin D-binding protein transports vitamin D metabolites in the circulation. Single nucleotide polymorphisms in the GC gene encoding vitamin D-binding protein are associated with circulating vitamin D metabolite levels in healthy infants and toddlers.
To test the hypothesis that GC single nucleotide polymorphisms encoding the D432E and T436K variants predict subsequent development of asthma in healthy children.
A retrospective medical record review was performed to determine the development of asthma in 776 children in whom GC genotype, vitamin D-binding protein concentration, and circulating 25-hydroxyvitamin D had been determined at 6 to 36 months of age. Demographic and detailed current clinical data were collected and criteria for asthma were recorded.
GC genotype was available for 463 subjects. After an initial analysis of all subject data, the analysis was limited to the predominant Hispanic population (72.1%) to minimize potential confounding effects of ethnicity. Asthma was diagnosed in 87 children (26%). Subjects with the GC genotype encoding the ET/ET (Gc1s/Gc1s) variant had lower odds of developing asthma, representing a protective effect compared with subjects with the DT/DT (Gc1f/Gc1f) variant.
In the Hispanic population of inner-city New Haven, Connecticut, the ET/ET (Gc1s/Gc1s) genotype of vitamin D-binding protein might confer protection against the development of asthma compared with the wild-type genotype DT/DT (Gc1f/Gc1f).
潜在的维生素 D 相关影响炎症性疾病，如哮喘，是有争议的，包括维生素 D 不足与哮喘发病率增加有关的建议。维生素 D 结合蛋白在血液循环中运输维生素 D 代谢物。维生素 D 结合蛋白编码基因 GC 中的单核苷酸多态性与健康婴儿和幼儿的循环维生素 D 代谢物水平有关。
测试 GC 基因编码 D432E 和 T436K 变体的单核苷酸多态性是否可以预测健康儿童随后发生哮喘的假说。
对 776 名儿童进行了回顾性病历审查，以确定在 6 至 36 个月时测定 GC 基因型、维生素 D 结合蛋白浓度和循环 25-羟维生素 D 后发生哮喘的情况。收集了人口统计学和详细的当前临床数据，并记录了哮喘的标准。
GC 基因型可用于 463 个主题。在对所有受试者数据进行初步分析后，分析仅限于主要的西班牙裔人群（72.1%），以最大程度地减少种族的潜在混杂影响。87 名儿童（26%）被诊断为哮喘。与 DT/DT（Gc1f/Gc1f）变体相比，携带编码 ET/ET（Gc1s/Gc1s）变体的 GC 基因型的受试者发生哮喘的几率较低，代表一种保护作用。
在康涅狄格州纽黑文市的西班牙裔人群中，与野生型基因型 DT/DT（Gc1f/Gc1f）相比，维生素 D 结合蛋白的 ET/ET（Gc1s/Gc1s）基因型可能对哮喘的发展具有保护作用。
